The 12th Invest in ME Research Conference June, 2017, Part 2
MEMum presents the second article in a series of three about the recent 12th Invest In ME International Conference (IIMEC12) in London.
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Vitamin B6 and P5P issues

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by SJB944, Feb 26, 2012.

  1. SJB944

    SJB944 Senior Member

    Has anyone experienced Neuropathy from P5P?

    I have high levels of P5P in the blood, so stopped taking all B6 for about 4 months, peripheral neuropathy symptoms seemed to ease a little, but came and went in waves of intensity still. Just started taking 50mg of P5P a day with a b-complex, and after about 2 weeks have notices a significant increase in tingling, prickling, buzzing in hands feet, mouth, stomach etc.

    I'm taking most basics, including 30mg of zinc which may also contribute to the neuropathy, Mb12 and ADb12.

    Can't find any research that suggest P5P can be toxic, rather only Pyridoxine hydrochloride?

  2. aquariusgirl

    aquariusgirl Senior Member

    I can't seem to get enough B6. I inject about 300mg a day and sometimes take another 100mg of P5P. Not following with testing yet. Not sure what the best tests are ...I'm told blood B6 is pretty useless. I tested once years ago & it was super high. No signs of neuropathy & my mood and brain is way better.

    I suspect this may be a subset thing... maybe to do with KPU, but then again susan costen owens (autism researcher) says it relates to oxolates & all the OAT tests of PWCs she has reviewed reveal an oxolate problem & these folks need B6 -- big dosages apparently.

    But lamp2kid posted about neuropathy issues with B6 on another thread. It's odd that we respond so differently. I'd like to understand y.
  3. ukxmrv

    ukxmrv Senior Member

    I can't take B6 as it makes me go all jittery and I feel poisoned. However I can tolerate P5P even in high doses. Sorry can't help.

    Had terrible neuropathy and my blood tests showed low folate at one point though. This was before I tried P5P. Much better from folate supplementation.
  4. Sallysblooms

    Sallysblooms P.O.T.S. now SO MUCH BETTER!

    Southern USA
    B6 can to damage to nerves for sure. I only take a little, I had problems with it, thankfully my legs bot better when I cut way down.

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