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Virus and Genes Involved in Causation of Schizophrenia

Discussion in 'Other Health News and Research' started by Waverunner, Mar 9, 2013.

  1. Waverunner

    Waverunner Senior Member

    Cytomegalovirus (herpes virus family) seems to be implicated in schizophrenia.

    Mar. 8, 2013 — Viruses and genes interact in a way that may increase the risk of developing schizophrenia significantly. This happens already in the developing fetus.

    An international team of scientists led by Aarhus University, Denmark, has made this discovery. As the first in the world, they scanned the entire genome of hundreds of sick and healthy people to see if there is an interaction between genes and a very common virus -- cytomegalovirus -- and to see whether the interaction influences the risk of developing schizophrenia.
    And it does.
    Women that have been infected by the virus -- and around 70 % has -- will have a statistically significant increased risk of giving birth to a child who later develops schizophrenia if the child also has the aforementioned gene variant. This variant is found in 15 percent. The risk is five times higher than usual, the researchers report in Molecular Psychiatry.
    No cause for alarm
    People infected with cytomegalovirus most often do not know it, as the infection by the virus, which belongs to the herpes virus family, is usually very mild. But the researchers stress that there is no cause for alarm -- even if both risk factors are present in mother and child, there may be a variety of other factors that prevents disease development in the child.
    But as schizophrenia affects 1 per cent of the global population, this new knowledge is very important.
    "In the longer term, the development of an effective vaccine against cytomegalovirus may help to prevent many cases of schizophrenia," says Professor of Medical Genetics at Aarhus University, Anders Børglum.
    "And our discovery emphasizes that mental disorders such as schizophrenia may arise in the context of an interaction between genes and biological environmental factors very early in life."
    natasa778 and Simon like this.
  2. vamah

    vamah Senior Member

    Washington , DC area
    Reading more and more about psychiatric illness being caused by infectious disease. Yet the presence of psychiatric symptoms are still a trigger for doctors to rule out anything besides giving psych meds and therapy. Something seriously wrong with this picture.
  3. Simon


    Monmouth, UK
    Thanks for this, Waverunner.

    If you haven't see it already the blog on Mady Hornig's talk about how genes and pathogens (and pot!) can lead to neuropsychiatric problems is worth reading (and not just cos I wrote it...). There seems to be a burgeoning field of study into how genes and environment (including bugs) can trigger psychiatric problems:
    Mady Hornig: How do you solve a problem like CFS?


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