Just to reiterate the rationale for taking more B2 with your ado & Me B12 - & less or no folate, carnitine & potassium - for those who haven't seen it: B2-deficient people (a fair few of us are, especially if we don't consume animal protein and/or dairy) can't recycle folate through the methylation pathway, so standard amounts of folate don't work - you need very big doses. That is the only way you can get the methyl groups from the folate cycle. You may sacrifice tons of methylfolate just to get one methyl group. This can result in 50-100 times the amount of folate in the cell that the cell needs, which deranges folate cycling. Similarly, if you're B2 deficient, you use up tons of B12, because you need the B2 for MTRR. In the organic acids (OAT) tests, there is a high tendency for people with CFS to be B2-deficient. CFS isn't a B12 problem: it's a B2 and B12 problem. You also need C, selenium, & a bit of iodine to make T3 & T4. If you get enough B12 (transdermal provides maybe 80% penetration; injections more), & add B2, you should only need small doses of folate - 1-5mg/day or less. If you are then methylating properly, you should make your own carnitine. I don't comprehend all this, nor can I prove it's true (tho it's working for me so far). But it seemed important to at least provide the theory for examination.