Jonathan Edwards
"Gibberish"
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In theory then, assuming that the patient could tolerate it, would plasmapheresis and RTX together be the best combination to get the mature B cells in the plasma and the already existing auto-antibodies? I know this is probably not realistic, but just curious if I am grasping the concept.
Is JC virus the "Jakob Creutzfeldt" virus in the US or something else? It seems that this virus (JC or Jakob Creutzfeldt) is a risk with IVIG and it sounds like it is a potential risk with RTX, too?
Sort of, for the first question, but there are technical issues about how to combine them.
JC virus causes progressive multifocal leucoencephalopathy, and is not the same as the prion of Jacob Creutzfeldt disease which is a spongiform encephalopathy. The risk with IVIG would be the latter although I think it is now screened out. Both are disasters and fortunately very very rare.