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The MAO, 2 MTHFRs, and the BHMTs look bad.
"Deplin
My notes on what I found in the research say that H595Y +/- is associated with a x1.5 increase in some risk. The other two are associated with x1.98 (R415C) and x3.0 (K350A) increase in some risk when homozygous, but untested or with no risk at all in their heterozygous form.The three MTRR SNPs potentially do something. You can tell this by the names - H595Y, meaning histidine at position 595 is changed to tyrosine, K350A, meaning lysine at position 350 is changed to alanine and R415T, meaning arginine at position 415 is changed to threonine.
In other words there is a change to the structure of the protein made by the gene.
I now have to rely on memory as to how significant these changes are and I can't remember!. I have just had a terrible computer virus which destroys the motherboard (it is so new that it gets under the radar of all current anti-virus software). I have recovered my data but it is still quarantined till we know more about this virus so I don't have access to my records.
Agreed. These are mutations which can (and probably do) have an impact, but it's going to be a pretty mild down-regulation.There is a thread on MTRR here which may be helpful. In any case a doubt that +/- will have a dramatic effect. Some supplementation with methyl B12 may be helpful.