Hi All, I'll try to keep this short and to the point but I just want to say this site has been a great resource for me! Over the past year I had some issues with tingling and burning in my feet, lack of energy and focus/concentration, and a worsening of my OCD. In July 2014 I tried methylfolate (quatrefolic) at 400mcg per day. At first it was great, the tingling in my feet calmed down and my mental clarity was great. This lasted only a few days and after that I didn't notice any benefit from the quatrefolic even at 800-1200mcg. I didn't notice any adverse effects at first either. One thing I did notice was brain zaps (similar to those I've had in the past from SSRI withdrawal). In August 2014 I began to develop brain fog and by September 2014 I had extreme irritability, panic attacks, depression, anxiety, suicidal thoughts, shortness of breath etc. I'd also get very spacey and blank out making it very hard for me to focus at work. I didn't make the connection that it could be the folate until this month and I've since stopped the methylfolate about 3 weeks ago. Some of the symptoms have lessened but I still have difficulty focusing, brain fog, etc. The depression hasn't really lifted too much either. It feels as if something is missing from behind my forehead. I also took cdp choline in early August (to help improve my memory) so I first thought it was an excess acetylcholine issue but now I'm thinking it could be overmethylation. My question is can what I've done be reversed? Some of the possibilities I thought it could be is overmethylation, a deficiency in another vitamin/mineral due to the excess folate I probably didn't need? I've read it can deplete B12 but I'm afraid to take methylB12 if I'm overmethylated. Should I try magnesium, b2, b6 etc. as they are important cofactors from what I've read here. A few things I'll note: A neurologist thinks my tingling was caused by excess b6 (verified by blood test) and I have had ticks in the past. ELISA & Western Blot were negative for lyme. I do have metal fillings but they've never caused me an issue in the past. Thanks in advance to everyone for taking the time to read this! You are all so knowledgeable and helpful and patient with so many people!