International ME/CFS and FM Awareness Day Is On May 12, 2018
Thomas Hennessy, Jr., selected May 12th to be our international awareness day back in 1992. He knew that May 12th had also been the birthday of Florence Nightingale. She was the English army nurse who helped to found the Red Cross as well as the first school of nursing in the world.
Discuss the article on the Forums.

TLR-2 and borrellia (lyme)

Discussion in 'Lyme Disease and Co-Infections' started by roxie60, Oct 25, 2014.

  1. roxie60

    roxie60 Senior Member

    Messages:
    1,787
    Likes:
    600
    Central Illinois, USA
  2. duncan

    duncan Senior Member

    Messages:
    2,108
    Likes:
    4,586
    I would interpret it the same way. I notice the publication date is 2005. It is also primarily a German endeavor, and that country hasn't been as quick as others to wholeheartedly adhere to IDSA Guidelines.

    I wonder if there were ever any follow-up studies.

    Incidentally, you would think the NIH would be following this lead, or even something similar, considering its principal, if not sole, focus these days is diagnostics.
     
    Last edited: Oct 26, 2014
  3. Valentijn

    Valentijn Senior Member

    Messages:
    14,281
    Likes:
    45,893
  4. duncan

    duncan Senior Member

    Messages:
    2,108
    Likes:
    4,586
    rsID? Boy, do I feel ignorant... This is gene talk? I can almost guarantee the NIH isn't looking at this relative to Lyme patients. :)
     
    Valentijn likes this.
  5. Valentijn

    Valentijn Senior Member

    Messages:
    14,281
    Likes:
    45,893
    It's been researched a fair bit regarding other infections, and it sounds like variations elsewhere in the gene often have a very significant impact.

    23andMe data for the rest of the gene looks very normal for 31 patients I have full data for, when compared to 31 controls. One possible exception is rs3804100 where we have 2 patients and 0 controls who are homozygous for the rare version. The usual homozygous prevalence is 1.2%, but we're at 6.5%. It could just be a fluke though, since it's pretty small sample size.
     
  6. duncan

    duncan Senior Member

    Messages:
    2,108
    Likes:
    4,586
    "23andMe data for the rest...looks very normal for 31 patients..." Lyme patients?
     
  7. Valentijn

    Valentijn Senior Member

    Messages:
    14,281
    Likes:
    45,893
    ME patients from this forum.
     
  8. duncan

    duncan Senior Member

    Messages:
    2,108
    Likes:
    4,586
    Understood. Thanks.
     

See more popular forum discussions.

Share This Page