The 12th Invest in ME Research Conference June, 2017, Part 2
MEMum presents the second article in a series of three about the recent 12th Invest In ME International Conference (IIMEC12) in London.
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Thyroid dysfunction and HIV

Discussion in 'Other Health News and Research' started by pattismith, Jan 13, 2018.

  1. pattismith

    pattismith Senior Member

    Prevalence of thyroid dysfunction and its correlation with CD4 count in newly-diagnosed HIV-positive adults – a cross-sectional study



    Prevalence of subclinical hypothyroidism in HIV-positive patients is reported to be high in those with severe immune deficiency.

    However, there is paucity of literature in newly-diagnosed HIV-positive population.

    Our aim was to estimate the prevalence of thyroid dysfunction and study its correlation with CD4 count in this population.

    In this cross-sectional study, patients presenting to the antiretroviral therapy clinic were screened with thyroid function tests, including thyroid stimulating hormone, free triiodothyronine, free thyroxine, and anti-thyroid peroxidase antibody levels at the time of diagnosis.

    Two hundred and twenty-five HIV-positive and an equal number of healthy volunteers were enrolled.

    The mean (SD) CD4 count in the study group was 147.1 (84) and 70.7% had advanced immune deficiency with CD4 count <200 cells/µL.

    The overall prevalence of thyroid dysfunction was 75.5% in the study group and 16% in the control group.

    Subclinical hypothyroidism was the commonest abnormality noted in almost 53%.

    Significant correlation was observed between CD4 count and thyroid stimulating hormone, free triiodothyronine, and free thyroxine levels (r = −0.86, r = 0.77, and r = 0.84, respectively, p < 0.0001 for all).

    The present study demonstrated high prevalence of thyroid dysfunction in HIV-positive patients.
    The dysfunction is subclinical in most cases and correlates well with declining CD4 counts.
    PinkPanda, ScottTriGuy and Ema like this.
  2. pattismith

    pattismith Senior Member

    in the results, they found

    isolated low fT3 = 7.6% (control = 0) Euthyroid Sick Syndrome
    overt hypothyroidism 8.4% (control = 5.33)
    subclinical hypothyroidism 53% (control 7.6)

    We found that there was a direct correlation between CD4 count and FT3 and FT4 values . There was an inverse correlation of CD4 counts with serum TSH levels


    Subclinical hypothyroidism (SCH) is defined as a serum thyroid-stimulating hormone (TSH) level above the upper limit of normal despite normal levels of serum free T4.
    Of patients with SCH, 80% have a serum TSH of less than 10 mIU/L.

    My concern would be : do we notice any correlation between CD4 count and thyroid dysfunctions in ME/CFS or Fibro as well?
    PinkPanda likes this.

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