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Thyroid, DHEA and Pregnenolone

Discussion in 'Other Health News and Research' started by pattismith, Jan 23, 2018.

  1. pattismith

    pattismith Senior Member

    We know for long that hypothyroidism lead to hypogonadism, but it's not all:

    Serum Dehydroepiandrosterone
    , Dehydroepiandrosterone Sulfate, and Pregnenolone Sulfate Concentrations in Patients with Hyperthyroidism and Hypothyroidism

    Noriko Tagawa, Junko Tamanaka, Aya Fujinami, Yoshiharu Kobayashi, Toru Takano, Shuji Fukata, Kanji Kuma, Hisato Tada, Nobuyuki Amino
    Published April 2000

    Background: Dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEA-S) have been suggested to have protective effects against cardiovascular disease, cancer, immune-modulated diseases, and aging. We examined serum concentrations of DHEA, DHEA-S, and pregnenolone sulfate (PREG-S) in patients with thyroid dysfunction.

    Methods: Steroids extracted with methanol from serum sample were separated into an unconjugated fraction (DHEA) and a monosulfate fraction (DHEA-S and PREG-S), using a solid-phase extraction and an ion-exchange column. After separation of unconjugated steroids by HPLC, the DHEA concentration was measured by enzyme immunoassay. The monosulfate fraction was treated with arylsulfatase, and the freed steroids were separated by HPLC. The DHEA and PREG fractions were determined by gas chromatography–mass spectrometry, and the concentrations were converted into those of DHEA-S and PREG-S.

    Results: Serum concentrations of DHEA, DHEA-S, and PREG-S were all significantly lower in patients with hypothyroidism (n = 24) than in age- and sex-matched healthy controls (n = 43). By contrast, in patients with hyperthyroidism (n = 22), serum DHEA-S and PREG-S concentrations were significantly higher, but the serum DHEA concentration was within the reference interval. Serum concentrations of these three steroids correlated with serum concentrations of thyroid hormones in these patients. Serum albumin and sex hormone-binding globulin concentrations were not related to these changes in the concentration of steroids.

    Serum concentrations of DHEA, DHEA-S, and PREG-S were decreased in hypothyroidism,
    whereas serum DHEA-S and PREG-S concentrations were increased but DHEA was normal in hyperthyroidism. Thyroid hormone may stimulate the synthesis of these steroids, and DHEA sulfotransferase might be increased in hyperthyroidism.

    • © 2000 The American Association for Clinical Chemistry
  2. drob31

    drob31 Senior Member

    This suggests hypothyroidism could cause an increased need for DHEA-S and PREG-S, which would lower these hormones, thus causing a decreased supply, which would lower cortisol, and cause hpa-axis dysfunction.
    sb4 likes this.

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