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Thiamine Deficiency uncovered

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by sregan, Apr 30, 2018.

  1. sregan

    sregan Senior Member

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    I was so focused on minerals I completely overlooked something.

    For the last few months I've been experiencing low energy, feelings of adrenal fatigue and just general feeling of going downhill and nothing I can do about it. Again... something is very wrong.

    For the second time in as many years I have been experiencing pretty severe alcohol intolerance. I wrote about it click here. I had a stressful holiday season and assumed my cortisol levels were bottomed out again.

    I started searching again and I have no idea how I missed this last year but vitamin B1, Thiamine, is the most likely place to look.

    Taking 100mg each morning with my regular B's and multi Mineral and so far so good. I've got energy and feeling very good and positive!

    I'm not sure why I was low on Thiamine to begin with. Wondering if methylation supplements can do that? Or possibly lack of Folate?
     
    Last edited: Apr 30, 2018
  2. mariovitali

    mariovitali Senior Member

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    Check a Gene called SLC19A3
     
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  3. Learner1

    Learner1 Forum Support Assistant

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    Thiamine is used in the transsulfuration pathway, along with molybdenum, to help rid the body of toxins mobilized in methylation. So, if you increase your methylation supplements, your need for B1 will increase.

    B1 also maintains the muscle tone in the walls of the digestive tract and promotes the health of the nervous system, skin, hair, eyes, mouth, and liver. and it improves the body’s ability to withstand stress. So, if these needs to go up you will need to get it from somewhere.

    My body seems to need about 700mg a day of B1, per my symptoms and lab testing
     
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  4. bjl218

    bjl218 Brian Levine

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    What would you say are the typical symptoms of low B1? I sometimes have trouble discerning the difference between the symptoms of too much B12/folate, too little B2, too little B1. Although I guess the symptoms might be different for everyone.
     
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  5. sregan

    sregan Senior Member

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    Thanks for that. I pulled up my genonme on 23andme and there's like 20 rows for this Gene. Apparently 19A2 is onvolved somehow. Do you know what rs# I'm looking for and what is the normal state for?

    I can take Thiamine and it does help.

    I found this: https://livewello.com/library/thiamine-metabolism-dysfunction-slc19a3?id=5307915007164416

    looks like a lot to sift through. I'll keep digging...
     
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  6. sregan

    sregan Senior Member

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    How can I make sense of this?

     
  7. sregan

    sregan Senior Member

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    I've been having IBS-D issues for a while now... I thought taking 100mg would be a lot although I've read that when low Doctors prescribe 500mg per day. Do you find that taking such high B1 depletes other cofactors?

    Are you taking other cofactors?
     
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  8. sregan

    sregan Senior Member

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    For me I just feel ill, old, run down, fragile, no energy. Typical CFS I would say. Adrenal fatigue for sure.
     
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  9. sregan

    sregan Senior Member

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    So maybe here: http://www.geneticlifehacks.com/thiamine-genetic-variations-in-need-for-b1/

    Out of the three Snps below I only have informaiton for rs28937595 which is ok @ C/C
     
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  10. Learner1

    Learner1 Forum Support Assistant

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    Yes, I am on a comprehensive program with all the cofactors, customized according to my labs.
     
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  11. Learner1

    Learner1 Forum Support Assistant

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    Poor appetite, weight loss, colitis and ongoing digestive problems like diarrhea, nerve damage and inflammation, fatigue, decrease in short-term memory, heart complications, and psychosis.
     
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  12. bjl218

    bjl218 Brian Levine

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    Wow. Ok, so I'm guessing I'm not suffering from severe B1 deficiency...

    @Learner1, you may have mentioned this previously, but what labs are you doing to monitor your nutrient status (other than NutrEval) and how often do you do these labs?
     
  13. Learner1

    Learner1 Forum Support Assistant

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    I do the NutrEval every 9-12 months. In between, my doctor will check MCV, homocysteine, various RBC minerals, and an amino acid panel through LabCorp. But they're not a substitute for the NutrEval. I also had an OAT test recently.

    While there's some overlap with the NutrEval, there are things unique to each trst, like lipids and antioxidants on the NutrEval.
     

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