Lipkin's Monster ME/CFS Study: Microbes, Immunity & Big Data
The Microbe Discovery Project outlines an ambitious new study by top researchers that has collected patient samples, but needs desperately funds to complete the work.
Discuss the article on the Forums.

T3 intracellular calcium and caffeine

Discussion in 'Other Health News and Research' started by pattismith, Jun 3, 2018.

  1. Iritu1021

    Iritu1021 Breaking Through The Fog

    Messages:
    543
    Likes:
    660
    What calcium channel openers do you know of?
    PTH regulates calcium absorption through its effect on intestines, Vit D activation and renal tubules. So if your CaSR settings are off then you can take more calcium but you're probably not going to absorb most of it. Both T3 and lithium stimulate PTH production.
     
    S-VV likes this.
  2. drob31

    drob31 Senior Member

    Messages:
    1,404
    Likes:
    872
    Other thoughts:

    I have arthritis worse in my finger joints. Although i use my fingers a lot but it's more prevelant in the last year.

    Malabsorption issues when eating would cause decreased calcium....
     
  3. drob31

    drob31 Senior Member

    Messages:
    1,404
    Likes:
    872

    I just googled it and saw something experimental called Bay K8644.
     
    Iritu1021 likes this.
  4. Iritu1021

    Iritu1021 Breaking Through The Fog

    Messages:
    543
    Likes:
    660
    @S-VV this was my hair analysis at the time of my big crash in 2014 post T3 and stimulant treatment for fatigue and Hashimoto's thyroiditis. I have the same low lithium as you do, and as you seem my calcium situation was even much more severe than yours (although the units are different).
    I do have documented low/borderline low ionized calcium but it seems to fluctuate and so does my PTH.
     

    Attached Files:

    S-VV likes this.
  5. Iritu1021

    Iritu1021 Breaking Through The Fog

    Messages:
    543
    Likes:
    660
    If it's a malabsorption issue than you should be able to get over it with Vit D and supplements. I don't think mine is due to malabsorption though since these supplements actually tend to make me worse (perhaps due to negative feedback on PTH). I'm pretty sure in my case it's something on the cellular level or hormonal regulation.
     
  6. drob31

    drob31 Senior Member

    Messages:
    1,404
    Likes:
    872

    Which supplements make you worse, vitamin D / calcium?

    I think that for those that have the same reaction to t3, something very similar is happening.
     
    Iritu1021 likes this.
  7. Iritu1021

    Iritu1021 Breaking Through The Fog

    Messages:
    543
    Likes:
    660
    Yeah, me too. I can definitely say that I've spent most of my life in two states: either "stressed" or "depressed".
     
    Last edited: Sep 16, 2018
    S-VV likes this.
  8. Iritu1021

    Iritu1021 Breaking Through The Fog

    Messages:
    543
    Likes:
    660
    Yes, too much Ca or Vit D makes me feel funky.
     
  9. drob31

    drob31 Senior Member

    Messages:
    1,404
    Likes:
    872

    Maybe cellular "calcium resistance" due to the CaSR mutation?
     
  10. Iritu1021

    Iritu1021 Breaking Through The Fog

    Messages:
    543
    Likes:
    660
    Maybe a defective receptor that can't regulate well either way so it's easy to overshoot?
     
  11. Iritu1021

    Iritu1021 Breaking Through The Fog

    Messages:
    543
    Likes:
    660
    And this is my hair analysis from this year. But my phosphorus is still low...
     

    Attached Files:

    S-VV likes this.
  12. drob31

    drob31 Senior Member

    Messages:
    1,404
    Likes:
    872
    Would having excess cause the same issues?
     
  13. drob31

    drob31 Senior Member

    Messages:
    1,404
    Likes:
    872
    By the way, as I sit here, I watch all these fasciculations occuring in my calves. Symptoms of low calcium or sodium or potassium or magnesium, etc?
     
  14. Iritu1021

    Iritu1021 Breaking Through The Fog

    Messages:
    543
    Likes:
    660
    No, it's a different set of issues. It switches me into a different "bad state".
     
  15. S-VV

    S-VV Senior Member

    Messages:
    206
    Likes:
    203
    Absolutely. I've been an overachiever my whole life, and I'm either wired, or tired, but never in the healthy middle.
     
  16. S-VV

    S-VV Senior Member

    Messages:
    206
    Likes:
    203
    There are two ratios that may help us, according to ARL:
    -Ca/K: reflects the effect thyroid hormone has at a celular level. Both yours (2014) and mine are above 30 which ARL says is hypothyroid.

    -Mg/Na: Reflects adrenal activity on tissue level. We both have a level below one. Severe adrenal insufficiency says ARL.

    http://www.arltma.com/Articles/RatiosDoc.htm

    This seems to paint a picture of insufficient cortisol and T3. It is interesting that your 2018 ratios have improved, for example your Mg/Na has gone from below one to two.

    We both are deficient in lithium (go team Li!), But I'm deficient in Iodine, where as you have too much. Could this be because you have primary hypothyroidism, ie, your not using the Iodine to make thyroid?
     
  17. Iritu1021

    Iritu1021 Breaking Through The Fog

    Messages:
    543
    Likes:
    660
    That is certainly one explanation - my iodine not being used up. My 2018 test is after supplementing with lithium which is why I wasn't deficient anymore. Have you ever tried lithium orotate? Or iodine? (and by the way, don't use them together, especially in high doses - that gave me a very bad reaction!)

    I found this on Wikipedia page: "ACTH, which probably controls cortisol by controlling the movement of calcium into the cortisol-secreting target cells." So if that's true than abnormality of calcium transport could be responsible for "adrenal deficiency' rather than vice versa...
     
    S-VV likes this.
  18. drob31

    drob31 Senior Member

    Messages:
    1,404
    Likes:
    872
    Remember how I mentioned b6 was helpful?

    I thought it was the HCL increasing stomach acid and allowing nutrient absorption. But...

     
    Iritu1021 likes this.
  19. SherDa

    SherDa

    Messages:
    59
    Likes:
    112
    I believe that mitochondria are supposed to be able to stockpile calcium because calcium binds to the phosphorus molecules in the phospholipids of the mitochondrial membranes. (I would encourage you to look this up rather than take my word for it though.) I don't know if this ties into the altered phospholipid levels found in recent studies or if low phosphorus levels could be contributing to the issue? Phosphorus also helps hold calcium in the bones.

    I need calcium supplements to function normally, but I have not reached a point of repletion after many months of supplementation. Serum calcium levels have always been normal. Since calcium greatly improves my energy levels, I believe it is being absorbed into the cells but the result is not sustained, and so I must take calcium periodically throughout the day. My calcium needs increase greatly when I take the fat-soluble vitamins to try to maintain bone health, as if I do not have enough calcium to maintain tissue levels and build bone. If I do not get enough calcium, I have greatly increased muscle tension/spasms (including my digestive tract), horrible cognitive function and extreme fatigue.
     
    Sidny and Iritu1021 like this.
  20. drob31

    drob31 Senior Member

    Messages:
    1,404
    Likes:
    872
    I get the spasms in my calves, and the fatigue and cognitive dysfunction.

    How much calcium do you take and how often, and what form?
     

See more popular forum discussions.

Share This Page