Researchers at Japan's RIKEN have found that activation of some kinds of T-cells changes their metabolism. This also causes shifts in availability of certain amino acids outside those cells, as they take up more. This is direct evidence, at least in mice, of a link between some forms of persistent immune activation and metabolomic changes. Does this match the kinds of metabolomic changes seen by Dr. Naviaux in human ME/CFS patients? Stay tuned.