Suplatast tosilate

[dreamydays]

I found an obscure drug (suplatast tosilate) used to lower Th2 cytokines. Would like some other eyes on this to see if it would be a candidate to test. The cytokines it inhibts are: IFN-γ, IL-2, IL-4, IL-5, CCL17, IL-12p70, IL-12p40, IL-13.

This is the montoya cytokine chart:

More info:
https://en.wikipedia.org/wiki/Suplatast_tosilate

https://www.tocris.com/products/suplatast-tosylate_3543
http://www.selleckchem.com/products/suplatast-tosilate.html

Available for sale here
https://www.mimaki-family-japan.com/item/detail?item_prefix=TF&item_code=006206&item_branch=001

 

[Ema]

@Hip, heard of this one?

 

[Hip]

I found an obscure drug (suplatast tosilate) used to lower Th2 cytokines. Would like some other eyes on this to see if it would be a candidate to test. The cytokines it inhibts are: IFN-γ, IL-2, IL-4, IL-5, CCL17, IL-12p70, IL-12p40, IL-13.

I am not sure about your list of cytokines, as it includes IL-12, IL-2 and IFN-γ which are actually Th1 cytokines.


If suplatast tosilate can increase the Th1 response by means of reducing the Th2 response, it might have some antiviral effects in ME/CFS. But I could not find anything that indicated suplatast tosilate can increase Th1. Th1 and Th2 are to some degree mutually inhibiting, so when one is high, it reduces the other. Thus in principle reducing Th2 might increase Th1.

 

[dreamydays]

The main research seems to be IL-4 IL-5 and IL-13. The other cytokines were mentioned on one of the research chemical sites selling it to labs.

 

[Hip]

The main research seems to be IL-4 IL-5 and IL-13.

That seems more like it.

Th1 cytokines = IL-12, IL-2 and IFN-γ
Th2 cytokines = IL-4, IL-10