nandixon
Senior Member
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- 1,092
23andMe doesn't provide the SNP marker for dysfunction in the endothelial nitric oxide synthase (NOS3) enzyme that Yasko uses, i.e., D298E (rs1799983). They do however give data for some 30+ other SNPs, including rs2070744. (https://www.23andme.com/you/explorer/gene/?gene_name=nos3) This SNP, while not a proxy/substitute for Yasko's, appears to be functionally as important, and might suggest the need for ammonia support/neutralization where the risk allele is present. A number of other SNPs reported by 23andMe may be significant as well.
So other people can check their results, here are the SNPs currently found on SNPedia for NOS3 (http://www.snpedia.com/index.php/NOS3) with my personal results and the "normal" (common) alleles in parentheses. Where I'm homozygous for the risk allele (+/+) I've also made some notations and given the percentage frequency of occurrence in the general population using the data from openSNP. I think I double-checked all my homozygous results against the actual research articles that SNPedia cited, so hopefully this is pretty accurate.
I had delayed looking into my NOS3 results because when I first checked them, all 30+ were showing as homozygous and so I figured I was fairly safe. That was not a good assumption:
rs11771433 No Data
rs1799983 No Data (Yasko marker D298E)
rs1800779 +/+ GG (AA) (associated w/ hypoxic-ischemic encephalopathy; 17% frequency)
rs180783 +/+ AA (TT) (proxy for rs4496877 - see below; 17% frequency)
rs2070744 T(-786)C +/+ CC (TT) (major issues w/ ammonia detoxification if similar to D298E => take yucca with meals and activated charcoal at bedtime; significantly lower promoter of endothelial NOS => reduced nitric oxide production; increased risk of rheumatoid arthritis, bladder cancer, progression of prostate cancer; 13% frequency)
rs3918188 -/- CC (CC)
rs3918226 -/- CC (CC)
rs3918227 -/- CC (CC)
rs4496877 +/+ AA (GG) (significantly increased nephropathy risk in type-1 diabetes; 13% frequency)
rs743507 +/+ CC (TT) (significant association w/ diabetic nephropathy; 7% frequency)
rs7830 -/- GG (TT)
So other people can check their results, here are the SNPs currently found on SNPedia for NOS3 (http://www.snpedia.com/index.php/NOS3) with my personal results and the "normal" (common) alleles in parentheses. Where I'm homozygous for the risk allele (+/+) I've also made some notations and given the percentage frequency of occurrence in the general population using the data from openSNP. I think I double-checked all my homozygous results against the actual research articles that SNPedia cited, so hopefully this is pretty accurate.
I had delayed looking into my NOS3 results because when I first checked them, all 30+ were showing as homozygous and so I figured I was fairly safe. That was not a good assumption:
rs11771433 No Data
rs1799983 No Data (Yasko marker D298E)
rs1800779 +/+ GG (AA) (associated w/ hypoxic-ischemic encephalopathy; 17% frequency)
rs180783 +/+ AA (TT) (proxy for rs4496877 - see below; 17% frequency)
rs2070744 T(-786)C +/+ CC (TT) (major issues w/ ammonia detoxification if similar to D298E => take yucca with meals and activated charcoal at bedtime; significantly lower promoter of endothelial NOS => reduced nitric oxide production; increased risk of rheumatoid arthritis, bladder cancer, progression of prostate cancer; 13% frequency)
rs3918188 -/- CC (CC)
rs3918226 -/- CC (CC)
rs3918227 -/- CC (CC)
rs4496877 +/+ AA (GG) (significantly increased nephropathy risk in type-1 diabetes; 13% frequency)
rs743507 +/+ CC (TT) (significant association w/ diabetic nephropathy; 7% frequency)
rs7830 -/- GG (TT)