sleep in patients with chronic infections

[Dufresne]

The results of my sleep analysis indicated I "woke up" 102 times! Yet I felt as though I slept through the night just fine. I've never done anything about this and just assumed it's part of the illness: altered brainwaves.

 

[physicsstudent13]

It would be great if I could finally know the cause of my horrid sleep disorder and brain fog, i.e. bacteria. According to my neurologist friend obstructive sleep apnea hypoxic events causes brain damage which causes central apnea as seen on DTI MRI

 

[Jammy88]

Go to the bottom. Says there is no credible evidence that it can be transmitted through Mosquitos


http://www.cdc.gov/lyme/Transmission/

It doesn't say it's transmitted sexually, either. However , it is and has been recently proved.

Best.

 

[JBB]

Go to the bottom. Says there is no credible evidence that it can be transmitted through Mosquitos


http://www.cdc.gov/lyme/Transmission/

CDC crap. All they are saying is that there has not been a study proving one way or another.

Of course mosquito's can transmit Borrelia - isn't this basic logic. Many stories of EM rash from it...just start speaking to Lymies.


Best wishes,

JBB

 

[physicsstudent13]

but how do you diagnose Lyme's? a result of 0.11 for igg/igm isn't accurate?
I was bitten by a mosquito and an hour later I had terrible migraines and weakness so severe I couldn't stand up and later nausea and vomiting

 

[msf]

I finally went through the article i posted the link for in the title post (thanks me for posting it!) and I'm glad I did - I found the last two paragraphs of the discussion part particularly interesting:

The present results suggest that with respect to a bacterial challenge, a presumed immune-supportive function for NREM sleep may be restricted to conditions of subtle host defense stimulation, for example, during the very early stages of infection.

In conclusion, the present study demonstrates that human sleep-wake behavior is very sensitive to host defense activation, probably via an endotoxin-induced release of inflammatory cytokines. These cytokines promote deep NREM sleep amount and intensity if the activation is subtle or leads to considerably disrupted sleep when a stronger activation occurs.

 

[msf]

The obvious inference here being that the affects of LPS on sleep might become deleterious the longer the infection lasts...this is pattern observed in many ME patients (according to KDM) and also the pattern I observed in myself.

 

[physicsstudent13]

I had noticable improvement in fog and heart function on rocephin. does that mean I have some sort of heart and brain infection or inflammation?
I'm curious to try this valcyte I do have the herpes zoster virus and a doctor said I had shingles- the virus remains for life in your brain stem

 

[August59]

I had a similar experience with my PCP. In his defense he did not know I had lyme, but believed all my symptoms were the result of poor sleep. On these grounds I agreed to do a sleep study. I felt like I slept maybe three hours cumulatively throughout the night and surprisingly my results indicated my sleep was very efficient. I now have 0 faith in these tests.

Since I was still symptomatic and having sleep difficulties the sleep specialist wanted to do another study on the grounds that I may be narcoleptic. I immediately declined and was in complete disbelief that he still felt my symptoms were caused by a sleep disorder. No where in literature is there a sleep disorders that causes all the symptoms seen with lyme.

Dr. Horowitz recently did a lecture where he said something along the lines of "you want to know if your patient has lyme? Throw every sleeping medication at them and they still won't be able to sleep".

Did the doctor explain to you that the "study" (MSLT) for narcolepsy is very different than typical sleep (PSGT)? In my case it didn't matter as my PSGT indicated excessive REM sleep and a big fat 0 for Stage 3 and 4 (Delta) sleep on 2 separate occasions. My MSLT which generally just looks at the rate of sleep onset and latency until REM sleep. The MSLT or "Nap Test" is performed during the day and includes 4 separate 30 min, (I think) "nap" sessions. On one occasion I fell into REM sleep sitting in the chair between naps.

Over the past 2 to 3 months I can't take a nap even with only getting 4 to 5 hours of 5am to 10am sleep.

Narcolepsy is now classified as an "Autoimmune Disease".

 

[physicsstudent13]

yes sleep disorders are terrible and really damage all of your organs from hypoxia low oxygen. I think I developed asthma and sleep apnea after working overseas
have you found a way to increase delta sleep? mine was also about 0 on a sleep study and I've been trying pharmaceuticals which seem to help

 

[August59]

have you found a way to increase delta sleep? mine was also about 0 on a sleep study and I've been trying pharmaceuticals which seem to help

No! My 3rd sleep study was performed while taking Xyrem and I only got 9 minutes of Delta sleep, which is better than the other 3 which were all "0".

Hopefully I'll be able to at least try Belsomra soon as I'm curious as to how effective it will be in promoting Delta sleep.

Edit: I'm just taking zolpidiem 10mg at the moment.

 

[physicsstudent13]

Yes this is a horrid disease and I've been disabled by the fogginess. On DTI MRI the brain develops damage and lesions of white mattter from repeated hypoxia, hundreds of thousands of hypoxic episodes a year. That's very interesting, I had 0.1% Delta sleep also.
I restarted klonopin+gabapentin and I had good clarity for 24 hours but on the 2nd night I had these gabapentin side effects of feeling unfocused cognitively impaired and spacy and wired

I have had neurofibromas removed surgically and do have tinnitus and hearing loss so maybe it's NF2?
I'm taking trazodone now and low dose gabapentin at 150mg but this doesn't seem to work that well. I'm so damaged I couldn't put the ventilator mask back on after waking up
I developed the severe and serious symptoms of asthma and sleep disorders after working overseas on faculty, could it be from an infection?

But my neurologist professor friend even with all of his knowledge and experience couldn't cure sleep apnea and had tracheosotomy

 

[msf]

http://www.ncbi.nlm.nih.gov/pubmed/7987701

I thought this was an interesting study, since the vagus nerve has been talked about with regard to ME.

 

[heapsreal]

The last several days while in the acute stage of shingles virus infection, my sleep went off ie waking up every hour so. Sometimes just get up and stay up for an hour or two. This was with sleep meds. The whole time I felt exhausted eith headache. One day I did manage to sleep a few hrs during the day which is unusual.

my guess would be increased inflammation of tje nervous system from vzv making it hard to sleep.

 

[msf]

Hi Heaps,

LPS seems to do this by increasing IL-6, so if viruses increase this too then the effect should be the same.

 

[msf]

http://jvi.asm.org/content/75/17/8008.short

I imagine it would be the same for the other herpes viruses.

 

[physicsstudent13]

I also vzv and seizures form yeras hypoxia asthma diabetes neuro inflammation and gluten carb diet. after attack left eye blind muscle weak can no pronounce or speak well anymore (was theologian). gabapentin with klonopin helps me clarity and terrible fog
maybe mycoplasma or tuberculosis and pseudomonas staphylococcus lung brain infection and hypoxia with asthma damage me cause seizures PLMD and heart damage tachycardia 125.

now on tinidazole plus doxy but dying slowly and can't breathe exhale

 

[msf]

Hi physicsstudent,

I haven't replied before because I didn't know what to say. I think it would be easier for others to suggest things if you concentrate on one issue at a time, but if you actually have this many things going on I really think you need to see a competent doctor - I don't know where you live but if I was you I would consider traveling (even to a different country) to see one. That is if you can afford it, of course. If you can't I would try to get doctors to address the areas they feel comfortable dealing with, such as TB - that way you can rule those things out/in.

 

[physicsstudent13]

was top of class in theology and also physics until got sick with terrible brain and lung diseases
TB mycoplasma granuloma with infectious disease? azithromycin bactrim flagyl doxy rocephin already but didn't help breathing, suffocating and need trach soon. last surgeon damage me with shiley 6

 

[Daffodil]

can you diagnose a brain infection or neuro inflammation with a SPECT or MRI? I actually have a crippling sleep disorder with seizures and wonder if it is from Lyme's?
I was bitten by a mosquito and about an hour later I came down with terrible migraines so bad I couldn't stand; I barely made it to the hospital where they gave me IV cipro/flagyl which didn't seem to work. I was nauseous and vomiting for about a week. I think I developed these seizures in my sleep a year later

hi physics. I think people with lyme can have seizures because of it. of course, seizures could be other things, too.

there are quite a few CFS patients I know who have seizures.