I have been doing research on this gene, as I suspect an underlying carnitine issue as a root of some of my issues. Currently, there is not much that I can find regarding which SNPs are relevant to carnitine deficiency, but I was hoping there may be someone who has more knowledge in this realm. This gene is associated with many conditions, including: hypoglycemia, Crohn's disease, lipid storage disease, arthritis, chronic fatigue, colitis, neuropathy, peripheral neuropathy, autonomic neuropathy, psoriasis, ulcerative colitis, etc. It seems a carnitine deficiency could certainly cause many problems outside of these defined diseases as well. Through searching on Promethease, Livewello, and Self Decode, I have a list of SNPs that I have mutations in, however very few of them have any data regarding the implications of these. Interestingly, my entire symptom set began occurring after infection with H. Pylori (blood test determined it was a "highly pathogenic" strain. Many of you are probably aware of Amy Yasko and her methylation research, and it seems that she has determined that H. Pylori may cause carnitine depletion, since it tends to raise Suberic Acid (a marker related to fatty acid oxidation). The link is here: http://feelgoodbiochem.com/chapter-7/. I have found no research to back this up, but it seems she has clinical experience with this. If this is the case, and I had the SNPs in this gene, it seems that I could have had carnitine issues before that were unveiled by the H. Pylori infection, but once again, I have no idea what these SNPs mean. I have tried L-Carnitine Tartrate and Acetyl-L-Carnitine, with mixed results. L-Carnitine Tartrate had a slightly positive effect, if any, and the Acetyl caused a negative reaction. I rememeber what @Freddd has written about L-Carnitine Fumarate being the missing link, so to speak, with carnitine, so this will be my next attempt. Here are the SNPs I have identified that I carry (Minor= minor allele, often called "risk allele if the SNP is found to have a negative impact) : rs1045020 C/T; Minor: T rs17689550 C/T; Minor: T rs2073642 C/T; Minor: T rs2073643 C/T; Minor: C rs2631359 C/T; Minor: T rs274557 C/C; Minor: C rs274558 G/G; Minor: G rs274567 T/T; Minor: T rs274570 C/T; Minor: T rs274571 A/G; Minor: G rs4646301 A/G; Minor: A rs635619 A/G; Minor: A rs17622208 G/G; Minor: G rs2631372 C/G; Minor: C rs2631367 C/C; Minor: C rs13180186 G/T; Minor: T rs2631361 A/A; Minor: A rs2631362 A/G; Minor: G rs2631363 G/G; Minor: G There are a few others as well that I personally do not have mutations on. I have a feeling this gene could be a big problem for some people, and I want to spark a conversation to dig up what people know.