Very interesting discussion with this thread. Also interesting because it matches some of the research that has recently been done on the illness. I always joked to my school friends that I had AIDS when I first started having CFS. I would simply catch everything around. Once around the 2-3 year mark though, I simply would not get ''really'' sick. I don't even remember the last time I have had a fever. A lot of people in this thread have some sort of point where their CFS went from causing them to constantly be sick, to never ''really'' being sick (no fevers), and it seems to often occur around the 2-5 year mark. Yes, I also have a difficult time wrapping my head around this one. From my personal experience and from what I have read in this thread, the first 3 years seem to feature what is an under active immune system, whereas the years after that feature an overactive immune system. For example, I have noticed that I have developed a lot of allergies (I never had allergies as a child, ever), and that I have almost chronic inflammation in my nose / mouth after the 3 year initial CFS period.. This points to what is an overactive immune system after the 3 year period. Some researchers are talking about ''immune-system-exhaustion'', after the 3 year period for CFS sufferers, but what does this mean? AIDS patients who had a deficient immune system would still get fevers if I recall correctly, although we do not. Then again, I will admit all my knowledge on the subject is of a very bro-science-esque nature, and I am feeling very drowsy at the moment .