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SHMT (+/-) while being MTHFR c677t (+/+) supplementation?

Discussion in 'Genetic Testing and SNPs' started by Anteah, Jan 5, 2013.

  1. Anteah

    Anteah Senior Member

    Las Vegas, Nevada
    Hi, anyone please shed a light. I assume with my setup there is no use in taking (wasting) folinic acid.. so then what are other ways of dealing with SHMT? I keep reading that it often causes gut disbiosis, and it is one of the main symptoms I'd like to part with asap, but there is really not much info on what the treatment really is. Yasko mutation specific supplements seem a bit confusing so far and pricey, plus tend to contain milk.. and that is a no go for me, so just trying to see if there is a cheaper and simpler way that someone is aware of of dealing w shmt?
  2. invisiblejungle

    invisiblejungle Senior Member

    I'm also SHMT+ and C677T ++.

    For SHMT, my doctor recommended SHMT Spray (or the individual components: hydroxy B12, folinic acid, lactoferrin, and nucleotides) and Ultimate B (or another B-complex). She said I may need to use the SHMT RNA later on, but it probably won't be necessary.

    Edit: Oops, nevermind I'm heterozygous for C677T, not homozygous.
  3. triffid113

    triffid113 Day of the Square Peg

    Well...I have the SHMT +/- and I have no dysbiosis. I don't know anything about SHMT though...I have too many genetic defects to research (I am overwhelmed). But I started taking 1g/day Olive Leaf extract 10 years ago when I noticed lowered stomach acidity, because HCL is needed to fend off pathogens in the gut. I have never thus had problems with such. I cannot supplement HCL because it takes zinc to make it and my zinc levels vary drastically with my allergy and supplementation status. Rhinitis allergies (and colds) damage mucous membranes and it takes high dose zinc to repair them which causes me to go hypothyroid, my adrenal gland to go out, and my stomach acid to wane.

    Regarding olive leaf extract, there is someone here who recovered from ME/CFS using Freddd's protocol plus a LOT of carnitine (5g/day or so, Drs. Best l-carnitine fumarate) and a combo of garlic extract and olive leaf extract to heal her gut (Velha508).

    6 Homozygous:
    COMT V158M +/+
    COMT H62H +/+
    ACE Del16 +/+
    MTRR A66G +/+
    BHMT 1 +/+
    CBS C699T +/+

    12 Heterozygous:
    VDR Taq +/-
    VDR Fok +/-
    MAO A R297R +/-
    MTHFR A1298C +/-
    MTRR 11 +/-
    BHMT 8 +/-
    AHCY 1 +/-
    AHCY 2 +/-
    AHCY 19 +/-
    CBS A360A +/-
    SHMT C1420T +/-
    NOS D298E +/-
  4. Lotus97

    Lotus97 Senior Member

    United States
    I'm new to SNPs so I don't understand this stuff too well, but dbkita posted about SHMT and folinic acid in this thread.

    I'd recommend checking it out because he seems to know what he's talking about it. Also in the thread there's another post by him about MTHFS, SHMT, and folinic acid.

    Are you referring to MTHFR C677T in regards to folinic acid? If so, I asked dbkita about that because it one time Rich also thought MTHFR C677T had trouble with folinic acid. There is some information at Yasko's site saying the same thing. But more recently Rich realized it was MTHFS (not MTHFR) and dbkita said the same thing about how it was MTHFS that has trouble processing folinic acid. There's a thread about this here:
  5. Diana S.

    Diana S.

    near LA, California
    Did you ever find an answer to your question? I have the same SNPs and have been supplementing with folinic acid but at 1/4 capsule every other day. I alternate the folinic acid with the L-5-MTHF.

    I just did a CDSA and have almost NO bacteria in my gut, good or bad. I'm on high dose probiotics and hope that will fix the problem. I believe B12 is generated by good gut bacteria so without bacteria, there is no B12 being generated.
    Hope you are getting better.

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