I have been using Samento -among other numerous treatments - for nearly 9 months (rotating them) and those last months, I am experiencing pain in legs (thigh + calves) that feels like tendinitis. I didn't know that using Samento may cause tendon damage, like quinolones do. And the reason is simple : "T.O.A.-free Cat’s Claw does have direct antibiotic properties and is also an anti-inflammatory and immuno-modulator. The antibiotic component of the herb is attributable to the considerable quantities of quinovic acid glycosides found in the herb, which are natural precursors to pharmaceutical antibiotics known as Quinolones." (from Rosner's book on Lyme http://www.lymebook.com/lyme-grapefruit-lauricidin-colloidal-silver-samento ) Dr James Schaller : http://www.personalconsult.com/articles/fluoroquinolonedamage.html "Fluoroquinolone Damage One serious side effect that is not commonly discussed with patients is tendon and other tissue damage with these antibiotics. The quinolones include Levaquin and Cipro and even the popular "Lyme-killing" herb Samento or "cat's claw." I think I am going to stop it for a while and see what happens... Maybe some of you know one or two natural supplements I may add to bring some repair/relief to the tissues ?