Not to be the party pooper, but I think that you might have the same reaction again. Do you know your SNPs?
Maybe adding tryptophan when you add the SAMe would lessen the anxiety effect, because with more tryptophan substrate you are grabbing more of the SAMe to support serotonin (lifting depression) formation rather than grabbing SAMe with the tyrosine substrate to make dopamine (anxienty, OCD).
And your diet controls how much tryptophan you have, but your body can keep making tyrosine out of other things, so tryptophan supplementation might be the way to go. Some like tryptophan, some like 5-HTP. Don't know if one would work better than the other for you. Tryptophan is cheaper.