salmonella before cfs/me

[jimmy86]

Did anyone have a salmonella infection prior to CFS/ME?

I remember that I had one 2 years before. It was treated with abx, but I got IBS afterwards. Then CFS with gut problems.

Does anyone have a lingering salmonella infection? Did you treat it? Did it help?

 

[Valentijn]

There are genetic mutations which can result in alterations to various parts of the Complement portion of the innate immune system. Some result in over-active responses, and some result in deficiencies where specific infections are not cleared. Mutations in one of those genes, FCN3, is known to specifically result in difficulty mounting a response to at least a couple Salmonella variants.

Do you know for sure that it was a Salmonella infection?

 

[jimmy86]

There are genetic mutations which can result in alterations to various parts of the Complement portion of the innate immune system. Some result in over-active responses, and some result in deficiencies where specific infections are not cleared. Mutations in one of those genes, FCN3, is known to specifically result in difficulty mounting a response to at least a couple Salmonella variants.

Do you know for sure that it was a Salmonella infection?

That is interesting.
Yes, I am sure that it was salmonella because I got tested several times while having this infection.

Do you have any reference article? Is it possible to test mutations in FCN3?

 

[Valentijn]

Do you have any reference article? Is it possible to test mutations in FCN3?

http://omim.org/entry/604973
http://www.genecards.org/cgi-bin/carddisp.pl?gene=FCN3

The mutation listed on the OMIM entry is tested by 23andMe on both the V3 and V4 chips as rs28357092 ("D"/deletion is the pathogenic mutation).

 

[Rvanson]

Did anyone have a salmonella infection prior to CFS/ME?

I remember that I had one 2 years before. It was treated with abx, but I got IBS afterwards. Then CFS with gut problems.

Does anyone have a lingering salmonella infection? Did you treat it? Did it help?

 

[Rvanson]

I believe I became I'll with ME shortly after a teriaki chicken dinner. Thought I was going to die. No proof since by the time I was well enough to see a doctor it would have been gone but symptoms fit samonella poisoning.

 

[Forbin]

I started a thread that went into this general idea, i.e. the significance of a food poisoning event preceding ME by as much as a couple years.

A reasonable objection is that food poisoning is common enough that linking a relatively remote case to the onset of ME would be hard to prove. On the other hand, I think that there's a difference between "common" food poisoning, which may last a couple of hours, and food poisoning which lasts days and may send you to the ER.


http://forums.phoenixrising.me/inde...-permanently-altered-by-food-poisoning.47886/