Hello everyone! I am starting this thread to document my efforts to achieve a long lasting remission. First, a bit about me. I am 21 years old, and study mathematics. I have always had problems with fatigue but two episodes stand out in my life: Keto diet: I started the Keto diet at 18 to deal with hypoglycemic crashes after eating. As many of you know, the first few days of low carb eating, you get what is called the "keto flu". I however, got another unexpected symptom: my lymph nodes enlarged, and they have stayed that way ever since. I was unable to continue the keto diet for more than two months due to a complete lack of energy. Once I upped my carb intake my health improved significantly Treating SIBO: Two years after the keto fiasco I was dealing with some extreme bloating (I looked 9 months preggo). I decided to go the natural antimicrobial route, employing Allicin, olive leaf extract, oregano, neem etc... During the two weeks I felt miserable, consoling myself that once the treatment was over, I would get better. Only I didn't. At this point I was about 50% functional, but over the next few months my energy and aerobic threshold gradually declined further. Lactic acid probiotics: Hoping to "rebuild" my flora, I took some standard probiotics. big mistake. They lower by aerobic threshold so bad I couldn't walk more that 10 minutes without what felt like a sever lactic acid buildup. In hindsight, the last thing I should have done was to introduce D-lactic-acid probiotics to my already acidic microbiome. A new symptom appeared that confirmed my long time suspicion of ME/CFS: Inmune activation after exertion. That is, sore throat, painful lymphatic glands etc.. My hypothesis is simple: I have a profound state of stable dysbiosis. It is known that diet changes radically impact the microbiome, and what could be more radical than dropping all carbs+fibre for the keto trial. Then, of course, the antimicrobials didn't help. Also, I have had IBS since I can remember, and was heavily treated with antibiotics as a child. What is my objective? To go from a stable disbyosis to a stable eubyosis. I don't want the fanciest microbiome. To be honest, I don't care if I develop Rheumathoid Arthritis or chrohn's 30 years later. All I want is to salvage what I can out of my life before it all comes crumbling down. My protocol consists of two broad phases: Phase 1: Antibiotics. Inspired by Ken Lassesens success stories, plus many anecdotal reports, I will go on a Jadin like protocol, rotating antibiotics and taking very specific probiotics (symbioflor-2 and C. butycurum ). I will use three main classes of antibiotics: tetracyclines, macrolides and azoles. Before starting the antibiotics, I will do one week of Nystatin 10^6 IU two times a day plus fluconazole 100mg once a day to prevent yeast problems. I will continue taking the nystatin during the totality of phase 1 and rotating the fluconazole two weeks on, two weeks off to avoid liver damage. Phase 2: If the antibiotics by themselves are not enough, I will do a DIY homemade FMT taking great care to preserve the anaerobic component, and using the delivery system pioneered by @Master4thDegree . Of course, this microbiome restructuring project is embedded in a larger health framework inspired by this graph: Tomorrow I will be procuring the Nystatin + Fluconazole and on Sunday I will begin the one week Yeast-only part of Phase 1. Thank you for reading and any advice is very welcome. Tagging @Learner1, @ljimbo423 and @Master4thDegree because I really value your input.