Role of ‘nuclear factor erythroid-derived 2’ (Nrf2)

[tinacarroll27]

Hi not sure if anyone has mentioned this research or not or if the research is complete or on going. I found it very interesting as I have just discovered I have gene mutations on this gene; Would be interested to see the out come of this research!
My genes:
rs10183914 NRF2 ++
rs35652124 NRF2 +-

https://www.meresearch.org.uk/our-research/ongoing-studies/combat-oxidative-stress/

 

[jason30]

Hi not sure if anyone has mentioned this research or not or if the research is complete or on going. I found it very interesting as I have just discovered I have gene mutations on this gene; Would be interested to see the out come of this research!
My genes:
rs10183914 NRF2 ++
rs35652124 NRF2 +-

https://www.meresearch.org.uk/our-research/ongoing-studies/combat-oxidative-stress/

Very interesting!
How did you find out that you have ++/+- ?
23andme shows me:

• rs10183914 C/C
• rs35652124 T/T

 

[tinacarroll27]

How did you find out that you have ++/+- ?

This may be a mistake as I assumed that C was the wild type for rs10183914 but I think that is wrong. I am new to genetics, so I would ignore that bit.
I didn't go through 23 and me but a company in the UK
https://mthfr-genetics.co.uk/DNA/index.html
I am CC for rs10183914, and according to the report I got from them the RISK ALLELES is C. So 2 risk alleles.
I am TC for rs35652124 (RISK ALLELES is T) so one risk allele.
They are both connected to your ability to deal with anti oxidant stress.
It says in report that for rs10183914: The minor T allele is associated with increased levels of Nrf2 protein so I presume C is less Nrf2 which would mean more problems with antioxidant stress.
For rs35652124 the T is associated with less Nrf2 protein.
Interestingly they mention that mold, fungus and EBV can apparently block Nrf2 sites.

 

[jason30]

Thanks Tina.

Grr that means I definately got less NRF2 protein. It corresponds to my research into NRF2.
I came on NRF2 after reading that mold can block NRF2.
I have read that DIM unblocks NRF2.

 

[tinacarroll27]

Thanks Tina.

Grr that means I definately got less NRF2 protein. It corresponds to my research into NRF2.
I came on NRF2 after reading that mold can block NRF2.
I have read that DIM unblocks NRF2.

Yes it looks like you have less NRF2.
It does say on my report: ''that DIM seems to be a compound capable of unlocking the Nrf2 promoter region.''
It also says:
''Caution: You need adequate levels of cellular glutathione if
you want to work on your Nrf2 expression. Increasing Nrf2
expression without supplying glutathione can contribute to
lower glutathione levels and therefore lower your defence
against oxidative stress, heavy metals mycotoxins, etc.''

Lab test recommended: GSSG:GSH ratio (Oxidised Glutathione
to Reduced Glutathione ratio)