Does anyone have any experience of combining Rituximab with injections of Filgrastim / Neupogen? I've been in touch with a couple of cancer patients with ME recently. One had complete remission of their ME symptoms for 5 months after treatment with Rituximab. The good effects started very quickly and they felt better on chemotherapy than they did with normal ME symptoms. The other patient didn't have any positive effects on their ME symptoms with Rituximab but due to getting repeated infections they had injections of Filgrastim during chemo to boost their white blood cells. Would the Filgrastim affect the B cells depletion to the extent that it would not have the positive effects for ME symptoms?