I have aggressive Mast cell activation syndrome (MCAS) and I finished the Rituxan loading phase 10 weeks ago exactly. In the beginning I thought it was helping a little because it felt like my intolerance to steroids was reduced a little, but 10 weeks my intolerance to steroids is just getting worse and my other symptoms are becoming worse. My B cells are still ablated. I'm on Xolair as well. My IgE was over a 1000 at one point. at the end of the 1st month on Rituxan my IgE was about 280 and on the 2nd month it was around 380. I believe it was the Rituxan that lowered it but it seems to be increasing now. Im gonna check it again at the end of this month. Is there a chance that the Rituxan may still work for me?