I am seeing my doctor again soon, and I am hoping to come away with a prescription for ritalin. I have ADD and I've taken it in the past, so I know it does work for me. I'm wondering what effect it has on the methylation cycle? I know it is a methyl donor, and it works as a dopamine reuptake inhibitor, and a norepinephrine reuptake inhibitor. Should I adjust my supplements whilst taking ritalin? I currently take venlafaxine 375mg daily, plus the following supplements - Cytoplan Wholefood Multi - Mutivitamin & Mineral containing 6mcg methylcobalamin and 400mcg methylfolate. Doctors Best Phosphatidyl serine Lecithin Opti3 Omega 3 EPA & DHA with added D3 Lithium Orotate L lysine (to help prevent the cold sores) Q10 D ribose Magnesium Malate Methylfolate 1600mcg Methylcobalamin 2000mcg Thanks for reading!