I stumbled across this study last night and found this somewhat concerning: "Research has focused on glycation by glucose, assumed to be the most relevant sugar in both non-pathological tissues and hyperglycaemic conditions. However, glucose is not an efficient glycating agent as it overwhelmingly adopts its thermodynamically stable pyranose form, rather than the reactive open-chain aldehyde form. Pentoses such as ribose and especially R5P (ribose-5-phosphate) are much more potent glycating agents, R5P reacting with amines 150-fold faster than glucose [4,5]. R5P and the mechanistically almost indistinguishable ADPR (adenosine diphosphate ribose) are both released into the extra-cellular matrix on cell necrosis, so are present in chronic inflammation where there is long-term cellular damage, and so could be potent biologically significant and, to date, under-investigated glycating agents." This is based on preliminary in vitro work, but just wondering if one is should be concerned if they're taking decent amounts of riboflavin, d-ribose, or R5P (the active form of riboflavin) and have glycation, inflammation or blood sugar issues?