Paper in the journal 'Science translational Medicine'
'Proinflammatory GM-CSF–producing B cells in multiple sclerosis and B cell depletion therapy'
http://stm.sciencemag.org/content/7/310/310ra166
@Jonathan Edwards I thought I should tag you on this one.
Editors Summary:
"Eclipsing multiple sclerosis
B cell depletion therapy (BCDT) has been shown to limit inflammation in some cases of multiple sclerosis (MS); however, how exactly BCDT works has remained unclear. Now, Li
et al. report that a subset of B cells that produce the cytokine granulocyte macrophage–colony stimulating factor (GM-CSF) contributes to MS pathogenesis. These cells are more frequent in MS patients than in healthy controls and increase proinflammatory myeloid responses. Moreover, production of these cells counterbalances the generation of interleukin-10 (IL-10)–producing regulatory B cells, which are thought to be protective in disease. After BCDT, the ratio of GM-CSF/IL-10–producing B cells is normalized, suggesting that BCDT may work in part by decreasing the number of pathogenic GM-CSF–producing B cells."