The 12th Invest in ME Conference, Part 1
OverTheHills presents the first article in a series of three about the recent 12th Invest In ME international Conference (IIMEC12) in London.
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Rea: Quantitative assessment of autonomic symptom burden in Postural tachycardia syndrome (POTS)

Discussion in 'Other Health News and Research' started by mango, Mar 26, 2017.

  1. mango

    mango Senior Member

    Quantitative assessment of autonomic symptom burden in Postural tachycardia syndrome (POTS)

    Natalie A. Rea, Corey L. Campbell, Melissa M. Cortez

    Journal of Neurological Sciences
    Published online: March 21, 2017 Accepted: March 20, 2017 Received in revised form: March 6, 2017 Received: December 5, 2016


    • Autonomic symptoms are significantly elevated in PoTS patients vs controls.
    • Autonomic symptoms in PoTS are not limited to orthostatic intolerance.
    • Model selection shows differing symptom contributions in PoTS vs autonomic failure.
    • Differences in autonomic symptom domain scores highlight areas for further study.
    Postural tachycardia syndrome (PoTS) is a poorly understood disorder characterized by excessive tachycardia in the upright position. In addition, patients with PoTS often complain of non-postural symptoms, including fatigue, gastrointestinal and vasomotor fluctuations.

    The present study quantitatively assessed autonomic symptom burden in PoTS patients (n = 32) using the COMPASS-31, compared to that of autonomic failure/neuropathy (AF/N; n = 47) and asymptomatic, healthy controls (n = 32). Using AIC model selection and regression analysis, we found differences in the contribution of individual COMPASS-31 domains, depending on the autonomic disorder.

    In PoTS, fatigue severity, orthostatic intolerance and pupillomotor symptom domains, contributed significantly to differences in COMPASS-31 scores compared to controls. In contrast, the secretomotor, gastrointestinal, bladder and vasomotor domains, contributed significantly to the AF/N model. Our results confirm an increase in autonomic symptoms across all functional domains in PoTS compared to controls, and with similar severity to AF/N, though with differing significant domain contributions.

    Our findings provide additional support that PoTS is indeed a syndrome of autonomic dysfunction beyond orthostatic intolerance, but also indicates the likelihood of disease-specific contributions to symptom burden, highlighting the need for application of expanded physiological assessment beyond orthostatic challenge, as well as disease-specific symptom assessment tools for use in PoTS.

    Postural tachycardia syndrome (PoTS), Autonomic symptoms, Fatigue, Pupils, Autonomic failure, Model selection
    ryan31337 likes this.

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