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RCCX MAY EXPLAIN OVERLAPPING SYNDROMES ASSOCIATED WITH CHRONIC ILLNESS (EDS-HT, CFS, FM, LYME, MCAS

Nielk

Senior Member
Messages
6,970
Hi Everyone,

I received this today and thought that it might interest some of the PR members.

PS This is my first time posting a thread, hope I am doing it right and at the right place! ;)

Did you leave out a link to this information?
 

pattismith

Senior Member
Messages
3,931
"there seems to be a frequently disabling epidemic involving a large number of syndromes/symptoms/diseases with overlapping symptoms affecting mainly young, vibrant, talented people (predominantly women)"..

I think I like very much this theory :)
 

drob31

Senior Member
Messages
1,487
  • Co-inherited gene mutations of the RCCX module may explain presence of clusters of genetic illness in families and individuals involving hypermobility/fibrosis (TNXB gene), chronic medical illness (CYP21A2 gene, i.e. EDS-HT, CFS/ME, FM, POTS, MCAS, etc.), psychiatric illness (CYP21A2 gene) and autoimmune diseases (C4 gene).
  • CYP21A2 gene mutations could confer a stress vulnerability for the development of chronic medical illness (EDS-HT, CFS/ME, FM, POTS, MCAS, etc.) via "21hydroxylase overwhelm" and via PTSD-wiring from CAPS (CYP21A2 Mutation Associated Neuropsychiatric Spectrum) plus negative events.
  • CYP21A2 gene mutations create a hormone milieu which could affect the developing brain, making it a "brain wired for danger" by age 5, also known as CAPS (CYP21A2 Mutation Associated Psychiatric Spectrum).
  • CAPS likely predisposes to 4/5 of the major psychiatric illnesses (anxiety disorders, mood disorders, attentional disorders, autism spectrum). Both "21hydroxylase overwhelm" and PTSD wiring associated with CAPS could cause stress-induced mitochondrial shutdown (Naviaux MD PhD).


@Hip @Valentijn