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ratio of adb12 to hydroxyb12?
- Thread starter Aerose91
- Start date
minkeygirl
But I Look So Good.
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- 4,678
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- Left Coast
@Aerose91 what is the ratio you saw for mb12 to adb12?
1:1
picante
Senior Member
- Messages
- 829
- Location
- Helena, MT USA
@Aerose91, my husband was taking HyB12 and AdB12 (+ L-carnitine).
2000 mcg HyB12
2500 mcg Dibencoplex (1/4 tab)
This combo worked to get him out of an overmethylated state (from taking the MeB12 & Mefolate). The HydroxyCbl mopped up the excess methyl groups and he felt good on this combo for over a month.
He has the double COMT mutations (both homozygous) and the MAO A (homozygous), so while the MeB12/ AdB12/ Mefolate protocol worked well initially, he became really messed up after a dose increase (neurotransmitter failure). Right then I raided his e-mail and found the "results are ready" message from 23andme, and figured out the trouble, and we went out and got some niacin.
Now he's back to the original protocol, but we've got the HyB12 and niacin on hand in case it happens again.
2000 mcg HyB12
2500 mcg Dibencoplex (1/4 tab)
This combo worked to get him out of an overmethylated state (from taking the MeB12 & Mefolate). The HydroxyCbl mopped up the excess methyl groups and he felt good on this combo for over a month.
He has the double COMT mutations (both homozygous) and the MAO A (homozygous), so while the MeB12/ AdB12/ Mefolate protocol worked well initially, he became really messed up after a dose increase (neurotransmitter failure). Right then I raided his e-mail and found the "results are ready" message from 23andme, and figured out the trouble, and we went out and got some niacin.
Now he's back to the original protocol, but we've got the HyB12 and niacin on hand in case it happens again.
@picante
Thanks for that explanation. I'm wondering about the hydroxyb12 mopping up methyl donors though. My understanding is that hydroxyb12 is a methyl donor, just a form that your body can convert to what it needs vs ramming mb12 down its throat.
Niacin helped me calm down from the overexertion from mb12 but unfortunately the damage was already done.
Thanks for that explanation. I'm wondering about the hydroxyb12 mopping up methyl donors though. My understanding is that hydroxyb12 is a methyl donor, just a form that your body can convert to what it needs vs ramming mb12 down its throat.
Niacin helped me calm down from the overexertion from mb12 but unfortunately the damage was already done.