Severe ME Day of Understanding and Remembrance: Aug. 8, 2017
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ratio hydroxycobalamin to methylfolate

Discussion in 'Detox: Methylation; B12; Glutathione; Chelation' started by dwith an a, May 16, 2016.

  1. dwith an a

    dwith an a

    best ratio for hydroxycobalamin to methlyoalate supplement:

    rdi is like 1 mcg b12 to 400mcg folic acid

    thats 400 to 1, but mtrr recycles Mb12 like 30-2000 times

    1 molcule of b12 is about three times the mass of 1 methylfolate
    so 1mg b12 would break down .33 mg methylfolate going by methinine cycle chart

    too much hydroxycomalamin will deplete methylfolate ( my experience and matches the methionine cycle you see on wikipidiea ect.)

    too much hb12 will also lead to rashes... polycythemia vera and clots...
    too much seems to cause neuropathy in me.. uthoffs phenomena ( while mefolate can make it go away sometimes)

    too little mfolate = depression ( google deplin)
    too much mfolate = (serotonin syndrome... in theory and possibly my experience but I cant judge for sure, but felt like it if I ate chesse or anything with much tyronise (ie. Cheese syndrome according to wikipidia))


    WHat is the best ratio I can go by... with those things in mind.

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