deleder2k
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Norwegian media: Researcher and doctor Anita Kåss is behind a medicine that treats rheumatoid arthritis, psoriasis and M.S. The licence agreement is now sold to the Japanese pharmaceutical company Astellas for 800 MNOK (100M USD, or 77M Sterling). Test results (not sure if this is the study i've pasted in or not) show effect within 5 days, compared to 12 weeks compared to todays medicines.
I think they said on the news that it was all based on the idea that many with R.A and other diseases improved while being pregnant. I know that many PWME improves while they are pregnant. Could this have to do with GnRH? What is your take on this @Jonathan Edwards?
https://www.ncbi.nlm.nih.gov/pubmed/26460564
"Gonadotropin-releasing hormone (GnRH) and pituitary gonadotropins, which appear to be proinflammatory, undergo profound secretory changes during events associated with rheumatoid arthritis (RA) onset, flares, or improvement e.g. menopausal transition, postpartum, or pregnancy. Potential anti-inflammatory effects of GnRH-antagonists may be most pronounced in patients with high GnRH and gonadotropin levels. Therefore, we investigated the efficacy and safety of a GnRH-antagonist, cetrorelix, in RA patients with high gonadotropin levels.
METHODS:
We report intention-to-treat post hoc analyses among patients with high gonadotropin levels (N = 53), i.e. gonadotropin levels>median, from our proof-of-concept, double-blind AGRA-study (N = 99). Patients with active longstanding RA, randomized to subcutaneous cetrorelix (5mg days1-2; 3mg days 3-5) or placebo, were followed through day 15. Only predefined primary and secondary endpoints were analyzed.
RESULTS:
The primary endpoint, Disease Activity Score of 28-joint counts with C-reactive protein (DAS28-CRP), improved with cetrorelix compared with placebo by day 5 (-1.0 vs. -0.4, P = 0∙010). By day 5, more patients on cetrorelix achieved at least a 20% improvement in the American College of Rheumatology scale (44% vs. 19%, P = 0.049), DAS28-CRP≤3.2 (24% vs. 0%, P = 0.012), and European League against Rheumatism 'Good-responses' (19% vs. 0%, P = 0.026). Tumor necrosis factor-α, interleukin-1β, interleukin-10, and CRP decreased with cetrorelix (P = 0.045, P = 0.034, P = 0.020 and P = 0.042 respectively) compared with placebo by day 15. Adverse event rates were similar between groups.
CONCLUSIONS:
GnRH-antagonism produced rapid anti-inflammatory effects in RA patients with high gonadotropin levels. GnRH should be investigated further in RA."
I think they said on the news that it was all based on the idea that many with R.A and other diseases improved while being pregnant. I know that many PWME improves while they are pregnant. Could this have to do with GnRH? What is your take on this @Jonathan Edwards?
https://www.ncbi.nlm.nih.gov/pubmed/26460564