A few months ago I started taking Mestinon and almost immediately I started feeling worse. I was chilled, constipated, and completely out of breath all the time. I stopped taking it a few weeks ago, and things are so much better--I had never realized what a luxury it is to be able to breathe deeply, or to hold a conversation without stopping halfway through a sentence to catch my breath. Has anybody else had these problems? After stopping the Mestinon my doctor recommended Midodrine. I'm uneasy about trying it because it raises blood pressure, and my resting blood pressure is in the normal range. Plus I spend much of the day lying down (usually propped up on pillows, but still), and information I've seen about the drug says that people shouldn't take it before lying down. On top of that, I have a strong family history of stroke (mother and grandmother). I'm very torn because I don't want to say no to trying something that could possibly help me, but I'm feeling like maybe the risks outweigh the benefits here. Have any of you had experiences with Midodrine? Does anybody have wisdom they could share? When I told my doctor about my concerns regarding Midodrine, he said that Florinef was also an option. Does anybody have experience with this drug? I just don't know what to do.