PSA: Copper is essential for methylation

[Deltrus]

https://en.wikipedia.org/wiki/Copper_deficiency#Methylation_Cycle

Another hypothesis is that copper deficiency myelopathy is caused by disruptions in themethylation cycle.[9] The methylation cycle causes a transfer of a methyl group (-CH3) from methyltetrahydrofolate to a range of macromolecules by the suspected copper dependent enzymemethionine synthase.[9] This cycle is able to produce purines, which are a component of DNAnucleotide bases, and also myelin proteins.[9] The spinal cord is surrounded by a layer of protective protein coating called myelin (see figure). When this methionine synthase enzyme is disrupted, the methylation decreases and myelination of the spinal cord is impaired. This cycle ultimately causesmyelopathy.[9]

http://www.ncbi.nlm.nih.gov/pubmed/18472229

One step of the methylation cycle is catalysed by methionine synthase, which is known to be cobalamin-dependent. Nitrous oxide specifically inhibits this enzyme by inactivating methylcobalamin, causing SCD in animals and humans. Both animal and human data suggest that methionine synthase also requires copper, implying that the enzyme may be involved in the pathogenesis of CDM. Another enzyme involved in the methylation cycle, S-adenosylhomocysteine hydrolase, may be regulated by copper. Although this enzyme is not cobalamin-dependent, its potential impairment in copper deficiency may contribute to the overall dysfunction of the methylation cycle. In cases of congenital deficiencies of methylation cycle enzymes, spinal and cerebral demyelination was observed, providing further support for a critical role of the methylation cycle in myelination.

The reason why I post this is that most of the methylation protocols don't seem to mention it. People who start the protocols probably have too much copper, but that will probably slowly change because of the high vitamin C doses and methylation supplements, both of which can use up copper. (vitamin C chelates copper so it is excreted through urine)