Protein in aspirin may reduce Alzheimer's disease risk, study suggests

[trails]

Thought this was interesting... http://www.foxnews.com/health/2015/...isease-risk-study-suggests.html?intcmp=hplnws

References other topics discussed in prior forum threads including GAPDH, salicylates, and licorice herb.

 

[valentinelynx]

Wow. Bad editing or something (on the part of Fox news): aspirin does not have any proteins in it, it is just acetyl salicylic acid. As far as I can tell from this badly written article, the study (PLOS one) found that salicylic acid binds to Glyceraldehyde 3-Phosphate Dehydrogenase (GADPH) preventing it from entering cells and triggering cell death, from what I gather from this badly written article. One sentence reads, "The anti-Parkinson's drug deprenyl already demonstrates GAPDH's ability to prevent entry into the nucleus and the corresponding cell death" which is totally garbled. Another says, "GAPDH primarily plays a role in glucose metabolism, but it also helps regulate plants’ immune systems." What the ?

Probably the original paper says something interesting, but I can't tell what from this summary.

 

[trails]

I agree with your assessment of the article. Its prompted me, though, to commence an internet search of related studies. I may or may not have read the study to which the article refers - I can't remember. Nevertheless, the studies I did read contained some very interesting information that may have direct relevance to CFS.

 

[trails]

This is the link to the study itself: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0143447

 

[Marco]

Funnily enough I was reading another Alzheimer's related article that found a correlation between reduced walking speed and the build up of amyloid plaques. Of course there could be other confounding factors and it was a cross-sectional study but it reminded me of the pathetic 6MWT results in the PACE trial.

http://www.medicalnewstoday.com/articles/303436.php

They speculate (in another article) that while there may be no physical impairment to muscles etc in early AD plaques may be building up in the brain's motor areas.