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Progressive brain changes in patients with chronic fatigue syndrome: A longitudinal MRI study

Discussion in 'Latest ME/CFS Research' started by mermaid, Jul 13, 2016.

  1. mermaid

    mermaid Senior Member

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    osisposis, AndyPandy and Comet like this.
  2. hixxy

    hixxy Senior Member

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    Abstract
    Purpose
    To examine progressive brain changes associated with chronic fatigue syndrome (CFS).

    Materials and Methods
    We investigated progressive brain changes with longitudinal MRI in 15 CFS and 10 normal controls (NCs) scanned twice 6 years apart on the same 1.5 Tesla (T) scanner. MR images yielded gray matter (GM) volumes, white matter (WM) volumes, and T1- and T2-weighted signal intensities (T1w and T2w). Each participant was characterized with Bell disability scores, and somatic and neurological symptom scores. We tested for differences in longitudinal changes between CFS and NC groups, inter group differences between pooled CFS and pooled NC populations, and correlations between MRI and symptom scores using voxel based morphometry. The analysis methodologies were first optimized using simulated atrophy.

    Results
    We found a significant decrease in WM volumes in the left inferior fronto-occipital fasciculus (IFOF) in CFS while in NCs it was unchanged (family wise error adjusted cluster level P value, PFWE < 0.05). This longitudinal finding was consolidated by the group comparisons which detected significantly decreased regional WM volumes in adjacent regions (PFWE < 0.05) and decreased GM and blood volumes in contralateral regions (PFWE < 0.05). Moreover, the regional GM and WM volumes and T2w in those areas showed significant correlations with CFS symptom scores (PFWE < 0.05).

    Conclusion
    The results suggested that CFS is associated with IFOF WM deficits which continue to deteriorate at an abnormal rate. J. Magn. Reson. Imaging 2016.
     
  3. John Mac

    John Mac Senior Member

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  4. *GG*

    *GG* senior member

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    Was going to ask what IFOF is, now I see it. WM is white matter?

    GG
     
  5. taniaaust1

    taniaaust1 Senior Member

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    yes this has been already posted, I was one of the participants of this 6 year study. Basically our white brain matter is shrinking faster then it should be and the longer we've been sick, the worst it is.
     
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  6. mermaid

    mermaid Senior Member

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    Oh apologies.
    I felt sure it must have been and scanned the studies on PR on recent weeks but just realised that the study date was back in April (the other date on the article was very recent so I was fooled and maybe I confirmed the results of the study by not thinking to check the date on the study! My brain is definitely not great and I live with someone whose brain is much sharper than mine though 6 years older).
    Sorry - happy to close the thread but I don't know how!
     
    Last edited: Jul 14, 2016

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