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Probiotic Therapy cured peanut allergy

Discussion in 'Mast Cell Disorders/Mastocytosis' started by ebethc, Aug 17, 2017.

  1. ebethc

    ebethc Senior Member

    this is a promising result in a therapy that challenges the immune system to find a new & improved homeostasis...

    Published by our friends at the Lancet..

    "...Tang, an immunologist and allergist, pioneered a new form of treatment that combines a probiotic with peanut oral immunotherapy, known as PPOIT. Instead of avoiding the allergen, the treatment is designed to reprogram the immune system’s response to peanuts and eventually develop a tolerance.

    It’s thought that combining the probiotic with the immunotherapy gives the immune system the “nudge” it needs to do this, according to Tang.

    Forty-eight children were enrolled in the PPOIT trial and were randomly given either a combination of the probiotic Lactobacillus rhamnosus with peanut protein in increasing amounts, or a placebo, once daily for 18 months.

    At the end of the original trial in 2013, 82% of children who received the immunotherapy treatment were deemed tolerant to peanuts compared with just 4% in the placebo group.

    Four years later, the majority of the children who gained initial tolerance were still eating peanuts as part of their normal diet and 70% passed a further challenge test to confirm long-term tolerance."
    sarah darwins, Mary and Jennifer J like this.

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