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Predictors of chronic fatigue in adolescents 6 months after acute EBV infection: a prospective study

Discussion in 'Latest ME/CFS Research' started by Murph, Sep 28, 2018.

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    Brain Behav Immun. 2018 Sep 24. pii: S0889-1591(18)30625-1. doi: 10.1016/j.bbi.2018.09.023. [Epub ahead of print]
    Predictors of chronic fatigue in adolescents six months after acute Epstein-Barr virus infection: a prospective cohort study.
    Pedersen M1, Asprusten TT2, Godang K3, Leegaard TM4, Osnes LT5, Skovlund E6, Tjade T7, Øie MG8, Wyller VBB9.
    Author information
    1
    Institute of Clinical Medicine, University of Oslo, Norway; Dept. of Pediatrics, Akershus University Hospital, Norway. Electronic address: marpeders@gmail.com.
    2
    Institute of Clinical Medicine, University of Oslo, Norway; Dept. of Pediatrics, Akershus University Hospital, Norway. Electronic address: tarjei.asprusten@gmail.com.
    3
    Section of Specialized Endocrinology, Dept. of Endocrinology, Oslo University Hospital, Norway. Electronic address: kgodang@ous-hf.no.
    4
    Institute of Clinical Medicine, University of Oslo, Norway; Dept. of Microbiology and Infection Control, Akershus University Hospital, Norway. Electronic address: truls.michael.leegaard@ahus.no.
    5
    Dept. of Immunology and Transfusion Medicine, Oslo University Hospital, Norway. Electronic address: uxlios@ous-hf.no.
    6
    Dept. of Public Health and Nursing, Norwegian University of Science and Technology, Trondheim, Norway; Norwegian Institute of Public Health, Norway. Electronic address: eva.skovlund@ntnu.no.
    7
    Fürst Medical Laboratory, Norway. Electronic address: ttjade@furst.no.
    8
    Dept. of Psychology, University of Oslo, Norway; Dept. of Research, Innlandet Hospital Trust, Norway. Electronic address: m.g.oie@psykologi.uio.no.
    9
    Institute of Clinical Medicine, University of Oslo, Norway; Dept. of Pediatrics, Akershus University Hospital, Norway. Electronic address: v.b.b.wyller@medisin.uio.no.
    Abstract
    INTRODUCTION:
    Acute Epstein-Barr virus (EBV) infection is a trigger of chronic fatigue and Chronic Fatigue Syndrome (CFS). This study investigated baseline predictors of chronic fatigue six months after an acute EBV infection.

    MATERIALS AND METHODS:
    A total of 200 adolescents (12-20 years old) with acute EBV infection were assessed for 149 possible baseline predictors and followed prospectively. We performed linear regression to assess possible associations between baseline predictors and fatigue (Chalder Fatigue Questionnaire total score) six months after the acute EBV infection. A total of 70 healthy controls were included for cross-sectional reference. This study is part of the CEBA-project (Chronic fatigue following acute Epstein-Barr virus infection in adolescents).

    RESULTS:
    In the final multiple linear regression model, fatigue six months after acute EBV infection was significantly and independently predicted by the following baseline variables (regression coefficient B[95% CI]): Sensory sensitivity (0.8[0.09 to 1.6]), pain severity (0.2[0.02 to 0.3]), functional impairment (1000 steps/day) (-0.3[-0.5 to -0.08]), negative emotions (anxiety) (0.4[0.2 to 0.6]), verbal memory (correct word recognition) (1.7[0.1 to 3.3]), plasma C-reactive protein (2.8[1.1 to 4.4] for CRP values >0.86) and plasma Vitamin B12 (-0.005[-0.01 to -0.001]).

    CONCLUSIONS:
    Development of fatigue after acute EBV infection is to a larger extent predicted by baseline variables related to symptoms and functions than to baseline variables reflecting infectious and immune processes.

    TRIAL REGISTRATION:
    ClinicalTrials, ID: NCT02335437, https://clinicaltrials.gov/ct2/show/NCT02335437.

    Copyright © 2018. Published by Elsevier Inc.

    KEYWORDS:
    Adolescents; Chronic Fatigue Syndrome; Chronic fatigue; Epstein-Barr virus infection; Infectious Mononucleosis

    PMID:
    30261303
    DOI:
    10.1016/j.bbi.2018.09.023
     

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