I have been following Fred's protocol for several years now and this is what I've discovered: Once you begin to add methyl donors, your body discovers that it wants them and when you stop, you have problems. I started B-12 sublinguals twice, the first time at 1/8 of the Enzymatic therapy 1000mcg tablet, and each time I ended up in the ER with atrial fibrillation, which resolved after several hours. My realization after the second event was that I not only needed B-12, it was necessary to my health and symptoms. And so it went.
I now use 3-4 sprays of the Methyl and Adenosyl/Methyl Oils per day.
Folate was more difficult. I've been up and down on dosages, somehow could never go higher than about 20mg/day without feeling my head was spinning and suffering ll those hyper feelings that you can get. But over these past several years, I slowly added many mineral by low titration. This occurred even before the methyl donors with magnesium and low dose iodine--about 200mcg/day--and continued after with selenium--to about 300mcg/day--molybdenum to about 225-300/day--copper--to about 2+mg/day, and just within the last five months boron--now to about 7mg/day.
The boron has been most challenging and confounding and, over time, for me, seemed to have a symbiotic relationship with folate. It took me nearly three months of misery to realize I needed much more folate. And amazingly, I am now able to take much higher doses. Believe me, this is not what I want, but my body has made clear via all the refeeding symptoms that I have grown familiar with, that my body wants and needs the higher folate doses.
I am currently up to about 35mg of folate/day and suspect I am not quite there yet, that is, to satiety.
In the interest of full disclosure, I have only recently--this past April--had all my amalgam safely removed, and have done about 6 rounds of Andy Cutler's Chelation Protocol at low doses of ALA. I am convinced that many of these chronic health issues have toxic metals and poor absorption at their root. And amazing as it may seem, I still believe there is a healing for each of us--with the right combinations of support.
I also rely on tests to see where my body has settled over relatively short periods of time. That is, I use the NutrEval at least once a year, and over the past year I have done it twice to confirm my hunches and keep me on track. I am about to have my first ever Doctor's Data Toxic and other Elements Hair Test. It ought to show mineral levels over the past few months and give me a sense of whether I am supplementing with them adequately.
And if you haven't done the 23andme genetics test, I would recommend it. I wouldn't have any faith in this approach if I hadn't been able to see where my genetic issues were.
My symptoms in addition to varied heart irregularities (only a few years ago a surgeon wanted to do a heart ablation on me--now it's not discussed at all with my cardiologist), have been fatigue, widespread muscular pain and atrophy, insomnia, depression and chronic ibs--all of which are benefitting from high doses of folate...
As to the depression: I can say with some certainty that when I feel weepy and find myself thinking of stepping out in oncoming traffic, it has reliably been resolved by higher folate. There are studies done of Deplin, which is nothing more than folate at 15-20mgs/day as an alternative to anti-depressants...:
https://www.news-medical.net/news/2...ong-term-value-of-Deplin-in-treating-MDD.aspx
Good luck to us all...
