I WOULD APPRECIATE IT IF EVERYONE COULD CONFINE THEIR RESPONSES TO OBJECTIVE TESTS. IF YOU ONLY HAVE A CLINICAL DIAGNOSIS WITH NO OBJECTIVE MARKERS, PLEASE RESPOND "NO". Interesting research and prominent hypotheses suggest that so-called "leaky gut" could be implicated in the pathophysiology of ME. I would like to know if people have been tested for leaky gut and, if so, what the results were. Different tests have different degrees of specificity and sensitivity, so please state in the comments what kind of testing you performed. The lactulose/mannitol test only measures the permeability of the small intestine so cannot rule out increased permeability of the colon. I performed this test as I was not aware of these shortcomings at the time. As such, and because my result was negative, I am choosing to respond "Yes - The results were inconclusive". If you had leaky gut in the past which has since been successfully treated, please let us know in the comments the impact of treatment on your health.