Hi all, new to the board, thanks for having me! Sorry if this ends up being a really long post. I'm a 26 year old male, have had issues throughout my life with fatigue, mood issues, often feeling very irritable, brain fog, and just generally not very good! In spite of this, I have had a FEW short periods, where I have felt great. To cut a long story short, I believe a big part of my issue to be gut related. Dysbiosis/candida, something to that effect. Everytime I can take kind of antifungal, be it coconut oil, garlic, pau d'arco etc, I get a 'die off' reaction. I've had issues with bloating my entire life, soft stools, feeling like crap after eating, digestio not feeling very good etc. I had a binge eating disorder for around 10 years, and did a few rounds of antibiotics as a kid... and also grew up on a terrible diet full of sugar and junk.. so I have no doubt in my mind thos things collectively have destroyed my gut lol. Thankfully, the binge eating disorder is fully resolved, and my relationship with food is now great. Now I am just trying to resolve my symptoms of fatigue, mood, irritability, brain fog, mild depression and anxiety etc and get my life back together. The last 4 weeks I have been working on gut health. All sugar removed, currently on almost a keto diet, whole foods only, have been using 50 billion CFU probiotic, antifungals, then rotated to sacromyces boulardii etc, a typical anti-candida approach which I believe is having benefits. However, it became very clear to me when I started this protocol that this is what triggers my symptoms over the years. When my body is flooded with toxins, it seems my liver can't keep up. I get a lot of symptoms of liver issues i.e. red itchy skin, fatigue, brain fog, abdominal bloating and water retention, but blood work shows my liver itself is actually healthy. My 23+Me test shows I have some polymorphisms which I believe may explain my issues. I presume if my methylation cycle isn't working properly, and potentially also issues with sulfur, then my liver can't function at 100%. Pair that with an issue like candida/dysbiosis which in curing causes a huge release of toxins, it makes for a pretty rough time. I believe sulfur may also be an issue as this week I was trying to include high sulfur foods to help my liver detox, but then started getting strong sulfur gas... so I suspect actually that pathway isn't working properly. I have methylfolate and methylcobalamin, I have tried taking these on a few occasions but can make me feel more anxious / worse, so I suspect I'm bottlenecked elsewhere. Here are my SNP results (heteros and homos): COMT V158M: +/- COMT H62H: +/- VDR Taq +/+ MTHFR C677T +/- MTRR A66G: +/+ BHMT-02 +/- CBS C699T +/- SHMT1 C1420T +- On a blood test a few months ago, my folate was in range but near the bottom, my b12 was actually top of the range.. However I did wonder, if I am MTRR homozygous for example, could b12 blood work alone by meaningless? I could be at the top of the range but still have issues as it can't recycle properly? Can methylation issues also cause liver dysfunction to the point it affects hormones? Reason I ask is because when I was a teen, I had quite severe gynecomastia (development of breasts in men) which I had surgery to remove the gland. I know this is also often common with liver dysfunction.. I suspect its my body struggling to remove/process estrogen, could that be linked to the issues above? The strange thing is, during the times I've felt best, I had a very limited diet of: chicken breast, green beans, almonds, avocado and sometimes kidney beans... What I wonder now is if this worked because A) it didn't feed candida b) I wasn't including any antifungal foods triggering die off C) its fairly low in sulfur D) and possibly the fact that the molybdenum and manganese helped with sulfur issues in combo with low sulfur diet.. As of today I have decided to try reducing my sulfur intake again as the last few weeks it has been higher (As I thought it would be helping my body remove toxins from die off), but after the sulfur smelling gas I presume it's not quite working that way. I was also taking some sulfur increasings supplements like turmeric, ALA, NAC which I'm going to stop. I am taking molybdenum, most days was 150mcg-300mcg however I've not discovered doses of upto 1000-1500mcg are considered safe, so might try going higher. The last coupe lof days I was taking methylfolate and methylcobalamin but haven't today, as figured I may be best to hold fire on them until I get the order correct. I could keep explaining forever and I'm sure I've just scratched the surface but I hope someone might be able to give me some direction/suggestions based on that, especially around the 23+Me results. I really feel like methylation issues could explain my years of fatigue, depression, anxiety, irritability etc.