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Plasma Metabolites Predict Severity of Depression and Suicidal Ideation in Psychiatric Patients-A M

Jackb23

Senior Member
Messages
293
Location
Columbus, Ohio
I know that this illness is completely seperate from mental illness, but I did found it cool that the authors used metabolomics and machine learning. Reason I am posting this is because they discuss how the kynurenine pathway can activate Microglia.

“The microglia hypothesis for psychiatric disorders including depression has been proposed by researchers around the world including our research team, suggesting that maladaptive microglial activation may induce various psychiatric symptoms [1417]. From a small volume of liquid, metabolomic analysis can simultaneously measure more than 100 metabolites including several tryptophan-kynurenine pathway metabolites, which are recently known to be involved in brain inflammation and microglial activation [18, 19].”

Am going to look at the studies they cite, next.