Phoenix Rising supports the Millions Missing global day of protest
Phoenix Rising is delighted to support the demands being made in the ME/CFS community’s first-ever global day of protest …
Discuss the article on the Forums.

Pharmacological effects of Withania somnifera root extract on GABAA receptor complex

Discussion in 'Other Health News and Research' started by heapsreal, Nov 9, 2012.

  1. heapsreal

    heapsreal iherb 10% discount code OPA989,

    Messages:
    8,997
    Likes:
    8,405
    australia (brisbane)
    A methanolic extract of W. somnifera root inhibited the specific binding of [3H]GABA and [35S]TBPS, and enhanced the binding of [3H]flunitrazepam to their putative receptor sites. The extract (5 micrograms) inhibited [3H]GABA binding by 20 +/- 6 per cent whereas a concentration of 1 mg of the extract produced 100 per cent inhibition. The extract (5-100 micrograms) produced 20 +/- 4 to 91 +/- 16 per cent enhancement of [3H]flunitrazepam binding. In functional studies using 36Cl-influx assay in mammalian spinal cord neurons, W. somnifera root extract increased 36Cl-influx in the absence of GABA. This effect on 36Cl-influx was blocked by bicuculline and picrotoxin; and enhanced by diazepam. These results suggest that the W. somnifera extract contains an ingredient which has a GABA-mimetic activity.
    http://www.ncbi.nlm.nih.gov/pubmed/1660034
     
    Enid likes this.

See more popular forum discussions.

Share This Page