Pandemrix Vaccine, Autoimmune Reaction, & Narcolepsy

[Gemini]

Pandemrix vaccine triggers antibodies that bind to hypocretin receptor 2 causing an autoimmune reaction leading to narcoplesy in genetically predisposed people...

"Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2"
http://www.ncbi.nlm.nih.gov/pubmed/26136476

There have been past posts on this topic, perhaps @Jonathan Edwards might comment on these new & intriguing findings?

Researchers are exploring if somehow unblocking the brain's receptor might allow the hypocretin system to recover...and how to make vaccines safer by removing the specific region of the protein that mimics the receptor.
"Narcoplesy link to pandemic flu vaccine becomes clearer," Science, 3 July 2015
http://www.ncbi.nlm.nih.gov/pubmed/26138959

Edit: To add Science link

 

[Valentijn]

They've associated it with the HLA-DQB1*06:02 haplotype.

 

[natasa778]

Whaaaa, a vaccine-induced 'durable antibody responses' triggering a debilitating, life-long brain disorder? This cannot be so. This mustn't be!

 

[natasa778]

They've associated it with the HLA-DQB1*06:02 haplotype.

uh huh

Thus, HLA-B*07 allele and the closely linked haplotype A*01 B*07 DRB1*0701 DQB1*0602 may serve as a marker for genetic susceptibility to autism ...

http://www.hindawi.com/journals/aurt/2014/242048/

 

[Gemini]

Pandemrix vaccine triggers antibodies that bind to hypocretin receptor 2 causing an autoimmune reaction leading to narcoplesy in genetically predisposed people...

Mentioned in the Science article is whether the virus itself--H1N1 or other influenza strains--can trigger narcolepsy.

Apparently cases increased in China after the 2009 pandemic where the vaccine wasn't used & researchers have found serum from some patients does bind to the hypocretin receptor.

Hope we hear more about this...