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P2X7 receptors, is it safe to block it?

Discussion in 'Other Health News and Research' started by pattismith, Oct 27, 2018.

  1. pattismith

    pattismith Senior Member

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    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5808178/

    Published online 2018

    The P2X7 Receptor in Inflammatory Diseases: Angel or Demon?

    Very good review that shows that P2X7 can be deleterious in some viral infection like Flu or HIV, but protective in Chlamydia Trachomatis infection, parasitic infestations, and fungal infections



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  2. Hip

    Hip Senior Member

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    You are referring to @necessary8's purinergic ATP signaling hypothesis of ME/CFS?

    Some potential P2X7 inhibitors are listed in this post, but I calculated in this post that most of these inhibitors will not be effective in vivo when you take them orally. So there don't appear to be many P2X7 inhibitors available to ME/CFS patients anyway. I calculated that high dose transdermal magnesium may have some P2X7 inhibition (high dose transdermal or injectable magnesium is an old well-known treatment of ME/CFS).
     
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  3. pattismith

    pattismith Senior Member

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    I thought the danger signal /Purinergic receptor activation ME/CFS hypothesis was from Robert Naviaux?


    if this hypothesis was confirmed, wouldn't we find polymorphism in the P2X7 gene in ME/CFS?
     
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  4. Hip

    Hip Senior Member

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    It is, but forum member necessary8 came up with a particular hypothesized mechanism (summarized in this post) based on Naviaux's general idea.
     

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