Hi, Everyone. I will be trying oxymatrine after I see some specialists to cover other medical (as these things go, this isn't going to take place soon ). Anyways, I've heard that it makes you feel worst before better. I wasn't sure what that means in way of fatigue? And for how long? I'm mainly bedbound, alone with no help. I don't know if I can take it without finding some help if it makes me worst than I am. Everything to do with being able to survive day by day is stretched to a point that I don't know if it's possible to stretch it any further without causing more serious problems. I'm curious, what your experience or knowledge is about fatigue with oxymatrine, how long will it last, and any suggestions please. Thank you for any help.