I have been trying many things for the past 4 years to heal from my fatigue, fogginess, depression, insomnia, and inability to be active without severe exhaustion afterward. When I came upon information on the methylation cycle, everything turned around for me. I started with a methylb12/folic acid/b6 sublingual dissolved in my lip, and choline. My temps shot way up, and I weaned myself off of my desiccated thyroid within a few days. My energy levels had improved, but I was still having CFS crashes if I exerted myself too much. Then I started taking TMG. The first two days I took 1000mg per day. Wow! But then I overmethylated, and had to cut down. But I did find that I stopped crashing all together. I also get this great sense of well being from it. I have since been working to find the balance between taking enough and not too much. I am also working in a multi from Methyl Life that doesn't have B12 or methylfolate so you can dose those separately. And then a few days ago I decided to try inositol for my sleep (NOTHING has worked), and lo and behold it totally puts me right back to sleep when I wake in the night. But, it's also a methyl donor. I need the TMG so I can keep on exercising, and the inositol to help me sleep, and I know I also want what's in the multi for balance, but I am overmethylating so easily… I read that if you take niacin along with the methyl donors it's like stepping on the gas and brake pedals at the same time. I feel like I have to pick and choose, and I'm wondering if there's an easier way. Would it be okay to take as much niacin as I need to in order to take the other supplements I need?