Dr Marvin Medows is doing a trial of IV saline vs WHO oral rehydration solution (ORS) in a clinical trial in PWME+OI. He says he has preliminary data that the oral solution may be better than the IV, but it's important that it's a glucose/sodium solution. I've tried electrolyte solutions without glucose before and they've done nothing. Prof Edwards has warned that overhydration via IV is known to lead to awful things such as pulmonary oedema so I don't see this as risk-free and I think we should be cautious. Some PWME here on PR have been using electrolyte solutions for a long time but I don't know how many have used a glucose/sodium solution - though some have. My cardiologist has agreed that I can try a litre a day (and not more than a litre) of a home-made oral rehydration solution (7 tsp sugar/1 tsp salt - but note that the WHO stuff has additional ingredients). He thinks I'll get enough potassium from food. He thought I should give it a go for a couple of months (I was surprised - I thought he'd expect to see results immediately). I suspect that this is one of those areas in which there's no good evidence about how to best take ORS, and there seems to be a bit of a chasm between cardiologists and autonomic specialists with possibly different advice from each, so I'd like to tap into the community's experience in terms of what people have been told by our doctors. My doctor expected that drinking ORS before bedtime would mean I'd be up all night peeing but it hasn't and I'd say I'm waking up less dehydrated (after only two nights, admittedly - might be a fluke). Otherwise I'm taking 200ml at five points throughout the day and away from food to try to make sure it's properly absorbed but is the advice that that's necessary? I forgot to ask my cardio. Do people drink it with straws to protect their teeth from the sugar? Any other tips and wrinkles, or warnings?