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Opinions on 23andme results (inc lab results)

Discussion in 'Genetic Testing and SNPs' started by moose216, Nov 13, 2015.

  1. moose216


    Hi All, Been reading these forms for quite some time, impressive what many of you have figured out. Just got my results and looking to start working on treatment. The results make sense given inconsistent results with prior supplementation. Best Supplement results have been GABA and Magnesium (Liquid). Have tried high quality B6, Methyl-B12, and every other solid vitamin with inconsistent, if any, results. From what I have researched it seems I should avoid MethylB12, and consider Methylfolate?

    Diagnosed CFS & also ADD/MDD/GAD, had a positive ana test but no dx on that until after the new year. Other background is I have a very strong avoidance defense tenancy. Higher IQ, functioning professional (most of the time), but a very slow processor and 'intense' in my head. Regular mood swings (Not sure quite BiPolar2, more will start making gains for a few weeks/months doing well, and then usually an external circumstance will occur that frustrates and sort of degrades my mood. Been on multiple ADs, best luck was with effexor, but was moderate at best. Also physically I have energy crashes, but I suspect these are related to anxiety. Had (Confirmed & Treated) Lyme's as a teenager, now 30.

    Had many Labs, most came back 'In range' Key ones - Serum Folic Acid - 17.4, P5P - 85, B12 - 939, Sodium many times comes back slightly low, or right at border of normal. Had many other things tested if you have any questions.

    Anyways just hoping for some more experienced opinions to input and make some recommendations. Thanks in advance!

    COMT V158M rs4680 AA +/+
    COMT H62H rs4633 TT +/+

    COMT P199P rs769224 GG -/-,
    VDR Bsm rs1544410 TT +/+
    VDR Taq rs731236 GG -/-
    MAO A R297R rs6323 T +/+
    ACAT1-02 rs3741049 GG -/-
    MTHFR C677T rs1801133 GG -/-
    MTHFR 03 P39P rs2066470 AG +/-
    MTHFR A1298C rs1801131 GT +/-
    MTR A2756G rs1805087 AA -/-
    MTRR A66G rs1801394 AG +/-
    MTRR H595Y not found n/a not genotyped
    MTRR K350A rs162036 AA -/-
    MTRR R415T not found n/a not genotyped
    MTRR A664A rs1802059 GG -/-
    BHMT-02 rs567754 CC -/-
    BHMT-04 not found n/a not genotyped
    BHMT-08 rs651852 CC -/-
    AHCY-01 rs819147 TT -/-
    AHCY-02 not found n/a not genotyped
    AHCY-19 rs819171 TT -/-
    CBS C699T rs234706 AG +/-
    CBS A360A rs1801181 GG -/-
    CBS N212N not found n/a not genotyped
    SHMT1 C1420T not found n/a not genotyped
    CYP1A1*2C A4889G rs1048943 TT -/-
    CYP1A1 m3 T3205C rs4986883 TT -/-
    CYP1A1 C2453A rs1799814 GG -/-
    CYP1A2 164A>C rs762551 AC +/-
    CYP1B1 L432V rs1056836 CC -/-
    CYP1B1 N453S rs1800440 TT -/-
    CYP1B1 R48G rs10012 CG +/-
    CYP2A6*2 1799T>A rs1801272 AA -/-
    CYP2A6*20 rs28399444 II -/-
    CYP2C9*2 C430T rs1799853 CC -/-
    CYP2C9*3 A1075C rs1057910 AA -/-
    CYP2C19*17 rs12248560 CT +/-
    CYP2D6 S486T rs1135840 CG +/-
    CYP2D6 100C>T rs1065852 AG +/-
    CYP2D6 2850C>T rs16947 GG -/-
    CYP2E1*1B 9896C>G rs2070676 CG +/-
    CYP2E1*1B 10023G>A rs55897648 GG -/-
    CYP2E1*4 4768G>A rs6413419 AG +/-
    CYP3A4*1B rs2740574 TT -/-
    CYP3A4*2 S222P rs55785340 AA -/-
    CYP3A4*3 M445T rs4986910 AA -/-
    CYP3A4*16 T185S rs12721627 GG -/-
    GSTP1 I105V rs1695 GG +/+
    GSTP1 A114V rs1138272 CC -/-
    SOD2 A16V rs4880 AA -/-
    NAT1 R187Q rs4986782 GG -/-
    NAT1 R64W rs1805158 CC -/-
    NAT2 I114T rs1801280 CT +/-
    NAT2 R197Q rs1799930 AG +/-
    NAT2 G286E rs1799931 GG -/-
    NAT2 R64Q rs1801279 GG -/-
    NAT2 K268R rs1208 AG +/-
    Last edited: Nov 13, 2015
  2. Krishol


    Hi, I can't give any info but I'm wondering where you got your results interpreted?
  3. TheChosenOne

    TheChosenOne Senior Member

    I have similar problems. Especially "Other background is I have a very strong avoidance defense tenancy. Higher IQ, functioning professional (most of the time), but a very slow processor and 'intense' in my head. Regular mood swings" and anxiety.
    How was your lyme treated?
    What works very well for my anxiety is p5p, as I suspect pyrrole.
  4. moose216


    Lyme was treated by antibiotic, this was 15ish years ago, I believe doxycycleen(sp?). I also had pneumonia secondary to this at the same time. Was beat down to a shell of myself. P5P is great - Ive had good luck with solgar gaba and the natural calm - the only two supplements (until a few days ago, below), I could 'feel.

    Started treatment a few days ago. I always knew high quality makes a difference, but wow does it make a difference. i had some start up reactions at 2000mcg b12 and roughly the same of the 5-(whatever the activated version of folate is called). Low dose niacin did help as folks recommend, too much made me tired.

    Since then cranked it up - probably 30,000 mcg methyl-b12 sublingual a day, just keeping a few in my lip always. 8,000mcg of the folate. I am then doing 50,000 iu Vitamin D (clear deficiency), garden of life raw A,C,E,Iron,Zinc (separate), mag, calcium, potassium. Taking Max B-nd by Primer labs for other B's. Liquid gluithaone, dha,epa, huge dose probiotics and enzymes. Intense rebuild attempt, have seen some decent improvements.

    I am starting to see how this could happened. Prior health issues, plus the poor genes, a few years of vegetarianism (didn't know better), and some years of partying pretty hard (numb the health pain) was enough to just have me stripped down of any good reserves of anything over the years.

    Positive results thus far - my eyes are producing natural tears for the first time in a year or two, clearer eye whites, reduced muscle tension, muscles feel stronger, skin pigment coming back and can see my veins again in my arm, some male improvements that would seem to reflect things starting to function, less sensitivity to cold. Markedly increased mood and more outgoing, still a bit of an early evening crash, but cant complain.

    Now lets hope I dont hit the 1 week plateau/crash I hear so much about. Any thoughts are appreciated. Happy to answer any questions about my history/progress, may just be slow to respond at times.

    Any one have success reversing cognitive decline? My time/spacial/planning/prioritizing/executive function/ADDness has just gone to crap in the last year.

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